{"id":"W2057776573","doi":"10.1074/jbc.m312823200","title":"DNA Methyltransferase 1 Knock Down Induces Gene Expression by a Mechanism Independent of DNA Methylation and Histone Deacetylation","year":2004,"lang":"en","type":"article","venue":"Journal of Biological Chemistry","topic":"Epigenetics and DNA Methylation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":103,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University","funders":"","keywords":"Histone methyltransferase; Histone; DNA methylation; Acetylation; Histone methylation; Methyltransferase; Histone H2A; Epigenomics; DNA methyltransferase; Epigenetics; DNA; Molecular biology; Genetics; Gene; Methylation; Chemistry; Biology; Gene expression","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000509994,0.0001755476,0.0002799762,0.00003660263,0.00005721362,0.00001414258,0.0001448657,0.0004292788,0.00002544161],"category_scores_gemma":[0.0001835257,0.0001351913,0.0001258538,0.00007506998,0.00008288208,0.00001165586,0.00005561548,0.000187831,3.562757e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003999599,"about_ca_system_score_gemma":0.00006709123,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00000520126,"about_ca_topic_score_gemma":6.178509e-7,"domain_scores_codex":[0.9987248,0.00007498608,0.0005660477,0.0002471493,0.0002321814,0.0001548154],"domain_scores_gemma":[0.9990371,0.00003083561,0.0004578007,0.0001492776,0.0001916619,0.0001333108],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001322024,0.0001244297,0.0002388483,0.00002170789,0.00004287136,0.000002546753,0.00004560171,0.00008116904,0.9980326,0.00001321431,0.00001169016,0.001253121],"study_design_scores_gemma":[0.001061889,0.0004060639,0.0009097728,0.00003124445,0.00003580949,0.00002306004,0.00005218059,0.000003133767,0.9950035,0.002089743,0.0002295544,0.0001540306],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9764357,0.004795123,0.01841449,0.00009614103,0.00006215208,0.00008804829,0.0000230466,0.000004451013,0.00008090617],"genre_scores_gemma":[0.9942417,0.001901057,0.003557323,0.00002512562,0.0001524644,0.000003467648,0.00008323601,0.00001108494,0.00002456954],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01780603,"threshold_uncertainty_score":0.551294,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01695044994645017,"score_gpt":0.2676263810447282,"score_spread":0.250675931098278,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}