{"id":"W2057791419","doi":"10.1074/jbc.m110.213470","title":"Phosphatidylethanolamines Modified by γ-Ketoaldehyde (γKA) Induce Endoplasmic Reticulum Stress and Endothelial Activation","year":2011,"lang":"en","type":"article","venue":"Journal of Biological Chemistry","topic":"Endoplasmic Reticulum Stress and Disease","field":"Biochemistry, Genetics and Molecular Biology","cited_by":52,"is_retracted":false,"has_abstract":true,"ca_institutions":"McMaster University","funders":"National Institutes of Health; Vanderbilt University; National Center for Research Resources; Heart and Stroke Foundation of Canada","keywords":"Endoplasmic reticulum; Chemistry; Lipid peroxidation; Phosphatidylethanolamine; Cell biology; Endothelial activation; Biochemistry; Unfolded protein response; Endothelium; Biology; Membrane; Oxidative stress; Phospholipid; Endocrinology; Phosphatidylcholine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000141494,0.0002975647,0.0001617659,0.0001210152,0.0001028782,0.0001998158,0.0001140653,0.0002416296,0.0009271539],"category_scores_gemma":[0.000123977,0.0001432024,0.0002966557,0.0001239569,0.0001510765,0.0001893952,0.000204742,0.0005512438,0.0001970839],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001756737,"about_ca_system_score_gemma":0.00008037874,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002668732,"about_ca_topic_score_gemma":0.0003531944,"domain_scores_codex":[0.999872,0.00002852337,0.00001270896,0.0000215648,0.00002377918,0.00004140922],"domain_scores_gemma":[0.9999241,0.00001539411,0.0000262058,0.00001096714,0.000009918865,0.00001342586],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001641382,0.00001905939,0.0001015842,0.00001887334,0.000005953793,0.00004691035,0.00001543453,0.00001486059,0.9992162,0.00002585142,0.00001088945,0.0003602246],"study_design_scores_gemma":[0.00001617285,0.0003669666,0.004630037,0.000004809591,0.00001452666,0.0001955163,0.00004409614,0.0003062187,0.9937373,0.00003533897,0.0006456475,0.000003219812],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9973028,0.0006933243,0.001134119,0.00005798604,0.00001750837,0.00002038384,0.0001018909,0.00002143011,0.0006507129],"genre_scores_gemma":[0.9961714,0.0007149861,0.001314416,0.00008268298,0.00000637863,0.00003274215,0.0002464257,0.000006462035,0.001424458],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0009271539,"threshold_uncertainty_score":0.003101647,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01868036712220038,"score_gpt":0.2296636074274999,"score_spread":0.2109832403052995,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}