{"id":"W2057814921","doi":"10.1016/j.nbd.2008.03.010","title":"Full length mutant huntingtin is required for altered Ca2+ signaling and apoptosis of striatal neurons in the YAC mouse model of Huntington's disease","year":2008,"lang":"en","type":"article","venue":"Neurobiology of Disease","topic":"Genetic Neurodegenerative Diseases","field":"Neuroscience","cited_by":117,"is_retracted":false,"has_abstract":false,"ca_institutions":"Child and Family Research Institute; University of British Columbia","funders":"National Institute of Neurological Disorders and Stroke","keywords":"Huntingtin; Neurodegeneration; Medium spiny neuron; Cell biology; Glutamate receptor; Biology; Huntington's disease; Transgene; Mutant; Huntingtin Protein; Receptor; Genetically modified mouse; Apoptosis; Molecular biology; Neuroscience; Striatum; Biochemistry; Internal medicine; Gene; Medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0001832278,0.0003174696,0.0005046522,0.0002112399,0.0001605013,0.00001062481,0.0005836467,0.00005833715,0.000009647933],"category_scores_gemma":[0.002000345,0.0002700347,0.0002532784,0.0002696337,0.0009331138,0.0001214748,0.0001875992,0.000151498,7.130358e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00000791314,"about_ca_system_score_gemma":0.0002482058,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0000150168,"about_ca_topic_score_gemma":0.000002818633,"domain_scores_codex":[0.9971628,0.0005499966,0.0007653203,0.0008074946,0.0002712632,0.0004430967],"domain_scores_gemma":[0.9975548,0.0008975901,0.0005376317,0.0006535291,0.0001212623,0.0002351864],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00165121,0.0005919457,0.007801557,0.0001964101,0.000008800965,5.864723e-7,0.0004003704,0.004098257,0.9849371,0.0001919707,0.00008032274,0.0000414315],"study_design_scores_gemma":[0.001466793,0.00045597,0.007454526,0.0000288339,0.0001235129,2.587781e-7,0.00006474891,0.003326024,0.9866202,0.0002475591,0.000005898578,0.0002056292],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9954938,0.00002399181,0.0001203255,0.0004735901,0.0000980613,0.000961969,0.00279374,0.00002390768,0.00001058374],"genre_scores_gemma":[0.9987114,0.00009470539,0.0001763398,0.0008047146,0.00004204303,0.00008418655,0.00002631202,0.00004045293,0.00001985745],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003217558,"threshold_uncertainty_score":0.9999752,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05290993507302883,"score_gpt":0.2687826631879455,"score_spread":0.2158727281149166,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}