{"id":"W2057817161","doi":"10.1074/jbc.m703699200","title":"Ca2+-dependent Activator Protein for Secretion 1 Is Critical for Constitutive and Regulated Exocytosis but Not for Loading of Transmitters into Dense Core Vesicles","year":2007,"lang":"en","type":"article","venue":"Journal of Biological Chemistry","topic":"Cellular transport and secretion","field":"Biochemistry, Genetics and Molecular Biology","cited_by":49,"is_retracted":false,"has_abstract":true,"ca_institutions":"Toronto Rehabilitation Institute; University of Toronto; University Health Network","funders":"","keywords":"Exocytosis; Secretion; Munc-18; Cell biology; Activator (genetics); Vesicle; Chemistry; Biophysics; Biology; Biochemistry; Gene; Membrane; Synaptic vesicle","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004658575,0.0001442745,0.0002708159,0.00002209311,0.00007738409,0.00001001639,0.0000939883,0.000318202,0.000008693797],"category_scores_gemma":[0.0002982587,0.0001160652,0.0002374155,0.00002866093,0.0001947656,0.000007249857,0.00001107555,0.00009221866,3.036918e-8],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003052039,"about_ca_system_score_gemma":0.00006556113,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000002396219,"about_ca_topic_score_gemma":0.00000155967,"domain_scores_codex":[0.9990249,0.000009901537,0.0004489912,0.0002212112,0.0000946768,0.0002003799],"domain_scores_gemma":[0.9991455,0.0001228622,0.0002202629,0.00007983414,0.0003142594,0.000117266],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.004661569,0.00006208441,0.0006452013,0.0002791682,0.00008172867,0.000003545647,0.00005546242,0.000001881585,0.9935978,0.00007467515,0.00001327147,0.0005235837],"study_design_scores_gemma":[0.001516637,0.0007831642,0.0004225797,0.00007951709,0.00007245914,0.00004493683,0.0003089316,0.00005406287,0.9950957,0.0006586993,0.0008169183,0.0001464177],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8163938,0.00025774,0.1827036,0.0001547853,0.00003350186,0.0003338462,0.0001106861,0.000003170319,0.000008920709],"genre_scores_gemma":[0.9946387,0.00004734806,0.004754931,0.00008130981,0.000204097,0.00002141915,0.0002238902,0.00001043294,0.00001790641],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1782449,"threshold_uncertainty_score":0.4733002,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02872366908047787,"score_gpt":0.2774636552721372,"score_spread":0.2487399861916593,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}