{"id":"W2057817161","doi":"10.1074/jbc.m703699200","title":"Ca2+-dependent Activator Protein for Secretion 1 Is Critical for Constitutive and Regulated Exocytosis but Not for Loading of Transmitters into Dense Core Vesicles","year":2007,"lang":"en","type":"article","venue":"Journal of Biological Chemistry","topic":"Cellular transport and secretion","field":"Biochemistry, Genetics and Molecular Biology","cited_by":49,"is_retracted":false,"has_abstract":true,"ca_institutions":"Toronto Rehabilitation Institute; University of Toronto; University Health Network","funders":"","keywords":"Exocytosis; Secretion; Munc-18; Cell biology; Activator (genetics); Vesicle; Chemistry; Biophysics; Biology; Biochemistry; Gene; Membrane; Synaptic vesicle","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001791383,0.0004258635,0.0003786464,0.0001746797,0.0002437129,0.0007228188,0.0002732273,0.0003056816,0.001233872],"category_scores_gemma":[0.0002966484,0.0002239152,0.0002892811,0.0001558515,0.0003848897,0.0004416529,0.0003215834,0.0006172012,0.0007277702],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005147456,"about_ca_system_score_gemma":0.0003052948,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003723904,"about_ca_topic_score_gemma":0.0003874071,"domain_scores_codex":[0.9998535,0.00001992169,0.00001659662,0.00003870788,0.00003533583,0.00003596476],"domain_scores_gemma":[0.9996693,0.00006968287,0.0001063263,0.00004174261,0.00003558846,0.00007732613],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00008630814,0.000005796806,0.0001992014,0.00003562195,0.000003999989,0.0000834606,0.000009618874,0.00004792816,0.9987527,0.0001227176,0.00002458339,0.0006280395],"study_design_scores_gemma":[0.00001662349,0.00007868972,0.009536161,0.000008242174,0.00001852774,0.0005412845,0.00002338399,0.001685309,0.9846627,0.00009311543,0.00332963,0.000006356921],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9883448,0.00333049,0.006456825,0.0001784499,0.00004787369,0.00002395739,0.000461944,0.0001169642,0.001038849],"genre_scores_gemma":[0.9930695,0.001113146,0.002568517,0.00006582957,0.00002214772,0.00003218909,0.001189146,0.0000508805,0.001888614],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001233872,"threshold_uncertainty_score":0.004127741,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02872366908047787,"score_gpt":0.2774636552721372,"score_spread":0.2487399861916593,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}