{"id":"W2057844985","doi":"10.1371/journal.ppat.1001177","title":"HTLV-1 Evades Type I Interferon Antiviral Signaling by Inducing the Suppressor of Cytokine Signaling 1 (SOCS1)","year":2010,"lang":"en","type":"article","venue":"PLoS Pathogens","topic":"T-cell and Retrovirus Studies","field":"Immunology and Microbiology","cited_by":83,"is_retracted":false,"has_abstract":true,"ca_institutions":"Centre Hospitalier de l’Université de Montréal; McGill University; Jewish General Hospital","funders":"National Cancer Institute; National Institutes of Health; National Institute of Allergy and Infectious Diseases; Canadian Institutes of Health Research; Canadian Foundation for AIDS Research","keywords":"Suppressor of cytokine signaling 1; Tropical spastic paraparesis; Cytokine; Biology; SOCS6; SOCS3; SOCS5; Gene silencing; Transfection; Leukemia; Virology; K562 cells; Interferon; Cancer research; Signal transduction; Immunology; Gene expression; Cell culture; Gene; Cell biology; Genetics; Suppressor; STAT3; Myelopathy","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00006922916,0.0002467113,0.0001814119,0.0002912084,0.0001256641,0.0003094377,0.00005079983,0.0001243893,0.0009489865],"category_scores_gemma":[0.0000818952,0.00008102286,0.0002466934,0.0001978285,0.0001761741,0.0001120044,0.0001179994,0.0002085195,0.0002796295],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002098211,"about_ca_system_score_gemma":0.00013298,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003112547,"about_ca_topic_score_gemma":0.0005774676,"domain_scores_codex":[0.999931,0.00000839564,0.00000542744,0.00001831578,0.000016396,0.00002042758],"domain_scores_gemma":[0.999945,0.00000646231,0.00002672427,0.000003381779,0.000006684133,0.00001176],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001155886,0.000009849536,0.003509113,0.00007287593,0.000007861276,0.00005819281,0.00002552194,0.00008106787,0.9927086,0.00007384566,0.00009288247,0.003244613],"study_design_scores_gemma":[0.00004407509,0.0008891249,0.1806096,0.00003897191,0.0001086632,0.001683396,0.0002179395,0.004427503,0.8034694,0.0003724168,0.008117706,0.00002124114],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9951648,0.001573934,0.00144086,0.00006047409,0.0000188868,0.00001627967,0.001018357,0.000100948,0.0006055406],"genre_scores_gemma":[0.9951084,0.0007702096,0.001743079,0.00006872453,0.00001491052,0.00001710911,0.001534503,0.000009793643,0.0007332449],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0009489865,"threshold_uncertainty_score":0.003174722,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01732729147267625,"score_gpt":0.2304332146715341,"score_spread":0.2131059231988578,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}