{"id":"W2057844985","doi":"10.1371/journal.ppat.1001177","title":"HTLV-1 Evades Type I Interferon Antiviral Signaling by Inducing the Suppressor of Cytokine Signaling 1 (SOCS1)","year":2010,"lang":"en","type":"article","venue":"PLoS Pathogens","topic":"T-cell and Retrovirus Studies","field":"Immunology and Microbiology","cited_by":83,"is_retracted":false,"has_abstract":true,"ca_institutions":"Centre Hospitalier de l’Université de Montréal; McGill University; Jewish General Hospital","funders":"National Cancer Institute; National Institutes of Health; National Institute of Allergy and Infectious Diseases; Canadian Institutes of Health Research; Canadian Foundation for AIDS Research","keywords":"Suppressor of cytokine signaling 1; Tropical spastic paraparesis; Cytokine; Biology; SOCS6; SOCS3; SOCS5; Gene silencing; Transfection; Leukemia; Virology; K562 cells; Interferon; Cancer research; Signal transduction; Immunology; Gene expression; Cell culture; Gene; Cell biology; Genetics; Suppressor; STAT3; Myelopathy","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002874598,0.0001872177,0.0003363791,0.00008197509,0.0001887911,0.00001145892,0.0002666489,0.0002255333,0.0002195333],"category_scores_gemma":[0.0002230425,0.0001238358,0.00008788142,0.0001652677,0.0002807582,0.00005318303,0.0001442802,0.0006435909,0.00008165493],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001294263,"about_ca_system_score_gemma":0.00002820313,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00009837507,"about_ca_topic_score_gemma":0.00006268154,"domain_scores_codex":[0.9988267,0.0001465882,0.0003393293,0.0002675313,0.00005160542,0.00036818],"domain_scores_gemma":[0.9991636,0.0003441058,0.0001488547,0.0002484136,0.00008228582,0.00001271731],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001052492,0.0001469415,0.01274024,0.00002768801,0.0001387095,0.000004092079,0.00177459,0.000006113853,0.9841843,0.00005172101,0.000304098,0.0005162137],"study_design_scores_gemma":[0.0004366421,0.0001962069,0.0008503722,0.00006812317,0.0000674418,0.000004849138,0.0007370242,0.00001191376,0.9963171,0.00004384549,0.001112748,0.0001536684],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9968445,0.001586008,0.00001181918,0.00013355,0.0006200588,0.0001809237,0.0001072478,0.00003589213,0.0004800175],"genre_scores_gemma":[0.999364,0.00005749325,0.0000625657,0.00005061928,0.00006828465,0.00001085436,0.00003621467,0.00002168326,0.000328238],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01213282,"threshold_uncertainty_score":0.5049875,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01732729147267625,"score_gpt":0.2304332146715341,"score_spread":0.2131059231988578,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}