{"id":"W2057851318","doi":"10.1038/sj.bjc.6604612","title":"Estimation of renal function and its potential impact on carboplatin dosing in children with cancer","year":2008,"lang":"en","type":"article","venue":"British Journal of Cancer","topic":"Chemotherapy-induced organ toxicity mitigation","field":"Medicine","cited_by":14,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Engineering and Physical Sciences Research Council; University College London; Cancer Research UK; Hospital for Sick Children; Children's Cancer and Leukaemia Group","keywords":"Carboplatin; Dosing; Medicine; Renal function; Urology; Cancer; Internal medicine; Oncology; Chemotherapy; Cisplatin","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001045256,0.00008611311,0.0002437751,0.0001336079,0.00003793644,0.00001133499,0.0000252544,0.00006023156,0.00009727092],"category_scores_gemma":[0.00002489635,0.00007937203,0.0000465971,0.0001646351,0.00003699555,0.0001804271,0.000003780656,0.0002393282,1.786297e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002228905,"about_ca_system_score_gemma":0.0002675101,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00113479,"about_ca_topic_score_gemma":0.0002706313,"domain_scores_codex":[0.999165,0.00002489847,0.0002868586,0.00009650107,0.0003189087,0.0001078164],"domain_scores_gemma":[0.9994358,0.00001064411,0.0003057779,0.00003990877,0.0001361027,0.00007175884],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.00318945,0.0002428039,0.3015923,0.00006847481,0.0005175396,0.0001692605,0.000501534,0.04861697,0.3652624,0.000002688813,0.0002451702,0.2795914],"study_design_scores_gemma":[0.003763672,0.000462199,0.8962381,0.001296848,0.00009246223,0.003341738,0.000009177118,0.001590108,0.09311964,0.00001429636,0.000001670198,0.0000700933],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9962262,0.003156078,0.0001881204,0.0001790767,0.00005349829,0.0001577004,0.00001399802,0.000004883167,0.00002046044],"genre_scores_gemma":[0.9981251,0.001348536,0.0001504768,0.00008309676,0.0002515682,0.000002424402,0.000004360676,0.0000180087,0.000016422],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.5946459,"threshold_uncertainty_score":0.3236698,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008832073011949012,"score_gpt":0.268805274641748,"score_spread":0.259973201629799,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}