{"id":"W2057853325","doi":"10.1021/pr049768z","title":"Study of Ligand−Receptor Binding Using SPME:  Investigation of Receptor, Free, and Total Ligand Concentrations","year":2005,"lang":"en","type":"article","venue":"Journal of Proteome Research","topic":"Analytical chemistry methods development","field":"Chemistry","cited_by":72,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Waterloo","funders":"Natural Sciences and Engineering Research Council of Canada; Eli Lilly and Company","keywords":"Chemistry; Ligand (biochemistry); Receptor; Ligand binding assay; Chromatography; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0007644916,0.0005732507,0.0005060037,0.0005055848,0.000282424,0.0003798324,0.0006010907,0.0006606297,0.0007282527],"category_scores_gemma":[0.0007149714,0.0002144814,0.000259793,0.0004544495,0.0004988599,0.0006553727,0.0003351884,0.0006801812,0.0004373161],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003089168,"about_ca_system_score_gemma":0.0004277523,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00141697,"about_ca_topic_score_gemma":0.001599825,"domain_scores_codex":[0.9993466,0.0001224826,0.00002466256,0.0001439409,0.0002900598,0.00007222164],"domain_scores_gemma":[0.9995741,0.0002918687,0.00002031476,0.00002516381,0.00006583201,0.00002276328],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00003086772,0.00001650995,0.0001973863,0.00009553701,0.000009213963,0.00004767855,0.00003470349,0.0001355582,0.9945408,0.0002817769,0.00002754207,0.004582432],"study_design_scores_gemma":[0.00000597485,0.0001823151,0.001782638,0.000006799854,0.00001399608,0.0002422864,0.00004309197,0.007271341,0.9883608,0.0002747801,0.001803782,0.00001215518],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.7294102,0.01062055,0.2541557,0.0002689232,0.00006896623,0.0003150345,0.000317331,0.0003719661,0.004471254],"genre_scores_gemma":[0.874794,0.006728618,0.1119076,0.000172661,0.00004399352,0.0002835578,0.0003908196,0.00005900917,0.005619733],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00141697,"threshold_uncertainty_score":0.004043043,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1355405917192137,"score_gpt":0.4021978136858282,"score_spread":0.2666572219666145,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}