{"id":"W2057853325","doi":"10.1021/pr049768z","title":"Study of Ligand−Receptor Binding Using SPME:  Investigation of Receptor, Free, and Total Ligand Concentrations","year":2005,"lang":"en","type":"article","venue":"Journal of Proteome Research","topic":"Analytical chemistry methods development","field":"Chemistry","cited_by":72,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Waterloo","funders":"Natural Sciences and Engineering Research Council of Canada; Eli Lilly and Company","keywords":"Chemistry; Ligand (biochemistry); Receptor; Ligand binding assay; Chromatography; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002718948,0.0001300539,0.0003936376,0.0002161205,0.0001238413,0.00004483362,0.0002909501,0.0001296614,0.0002298428],"category_scores_gemma":[0.001731005,0.0001151276,0.00006482589,0.0004733602,0.0002815372,0.0002390865,0.0001839648,0.0006863939,0.000002610804],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002807837,"about_ca_system_score_gemma":0.0004949264,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0000188908,"about_ca_topic_score_gemma":0.000002336889,"domain_scores_codex":[0.9971998,0.0001623532,0.0009536275,0.0001879847,0.001203466,0.0002927517],"domain_scores_gemma":[0.9977047,0.0003732258,0.0005231089,0.0002269304,0.0009246545,0.0002473617],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00009955963,0.0002077979,0.01665269,0.000236728,0.0001192229,0.000004572727,0.001629825,0.00002521569,0.9805034,0.00001453185,0.0001001097,0.0004063479],"study_design_scores_gemma":[0.001228103,0.0002000906,0.000808763,0.0003953559,0.00003080875,0.00003392217,0.003127484,0.000195608,0.9936768,0.0001166184,0.00008231479,0.0001040789],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9986361,0.0001755441,0.0003646863,0.0002923593,0.0000265677,0.000221423,0.00001333724,0.000004576018,0.0002654539],"genre_scores_gemma":[0.9407718,0.00005362795,0.05854499,0.000001831818,0.0002583852,0.000006252794,0.000002269358,0.00001679863,0.0003440792],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.05818031,"threshold_uncertainty_score":0.4694768,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1355405917192137,"score_gpt":0.4021978136858282,"score_spread":0.2666572219666145,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}