{"id":"W2057879138","doi":"10.4161/isl.3.6.17766","title":"AEB071 (sotrastaurin) does not exhibit toxic effects on human islets in vitro nor after transplantation into immunodeficient mice","year":2011,"lang":"en","type":"article","venue":"Islets","topic":"Pancreatic function and diabetes","field":"Medicine","cited_by":3,"is_retracted":false,"has_abstract":true,"ca_institutions":"Diabetes Canada; University of Alberta","funders":"University of Alberta; Diabetes Research Institute Foundation","keywords":"Islet; Transplantation; Sirolimus; Apoptosis; Internal medicine; Endocrinology; Glucose homeostasis; In vitro; Insulin; Biology; Medicine; Pharmacology; Insulin resistance","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001891759,0.0002472502,0.0003522919,0.0002680458,0.00007021063,0.0000183394,0.00008388807,0.0001287062,0.0004337302],"category_scores_gemma":[0.00005182995,0.0001858334,0.0001140327,0.0001619267,0.00005600621,0.0001028844,0.00001543461,0.0002299719,0.0004392573],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001153168,"about_ca_system_score_gemma":0.00002902608,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000248882,"about_ca_topic_score_gemma":0.00002151812,"domain_scores_codex":[0.9985367,0.00008650688,0.0003385153,0.0003870067,0.0003003076,0.0003509319],"domain_scores_gemma":[0.9993187,0.0001369858,0.00007057243,0.0003154781,0.00004343492,0.0001148835],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.003230173,0.00050515,0.001416935,0.0003844699,0.00003546823,0.0002967319,0.003445985,0.000001151719,0.9871917,0.00007176618,0.00008250584,0.003337924],"study_design_scores_gemma":[0.002914065,0.0005813012,0.0552123,0.0003722047,0.000102514,0.00001579763,0.00008958658,0.00002770244,0.9400599,0.0001193494,0.0002887044,0.0002165563],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9903422,0.0001386976,0.00006438052,0.0002205583,0.0004517716,0.0004935727,0.00001630254,0.00008935951,0.00818318],"genre_scores_gemma":[0.9963478,0.00002514821,0.0004081706,0.002157228,0.0001032191,0.0001340024,0.00004640064,0.00003310391,0.0007449603],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.05379536,"threshold_uncertainty_score":0.7578067,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01512180752289095,"score_gpt":0.2515803071995461,"score_spread":0.2364584996766552,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}