{"id":"W2057886846","doi":"10.1097/01.jto.0000283106.85632.e3","title":"A3-03: Pemetrexed for the treatment of advanced non-small cell lung cancer (NSCLC): Results from a randomized phase III dose finding trial in patients who progressed following platinum-containing chemotherapy","year":2007,"lang":"en","type":"article","venue":"Journal of Thoracic Oncology","topic":"Lung Cancer Treatments and Mutations","field":"Medicine","cited_by":4,"is_retracted":false,"has_abstract":false,"ca_institutions":"Eli Lilly (Canada)","funders":"","keywords":"Pemetrexed; Medicine; Internal medicine; Lung cancer; Docetaxel; Chemotherapy; Oncology; Interim analysis; Performance status; Phases of clinical research; Toxicity; Randomized controlled trial; Gastroenterology; Surgery; Cisplatin","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001798525,0.001309141,0.002775285,0.0003974081,0.0004653223,0.001204673,0.001259008,0.001762489,0.004805762],"category_scores_gemma":[0.001434317,0.0005534331,0.002227632,0.0007024308,0.00136029,0.001317072,0.0004174713,0.00463815,0.0007934614],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0009049657,"about_ca_system_score_gemma":0.001413314,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002095471,"about_ca_topic_score_gemma":0.004272914,"domain_scores_codex":[0.9995462,0.0002305003,0.00002651768,0.00006853975,0.00003694908,0.00009114546],"domain_scores_gemma":[0.9991068,0.0002396156,0.0001700439,0.00006708605,0.0000367939,0.0003795197],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.928808,0.01283014,0.002131116,0.0005324823,0.001553926,0.00009511077,0.0001027171,0.001231447,0.006821197,0.0001754437,0.002381085,0.0433375],"study_design_scores_gemma":[0.9245279,0.06785786,0.00467223,0.00001908399,0.0005379809,0.0001060007,0.0000319621,0.0006701097,0.0007483285,0.0001982405,0.0006123125,0.00001795872],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9939367,0.001915086,0.0002658094,0.0007889725,0.0001637214,0.0007765081,0.001044139,0.0001081566,0.00100091],"genre_scores_gemma":[0.9912468,0.002229628,0.0009595455,0.001179276,0.0001869221,0.001035667,0.001484668,0.00004154527,0.001635892],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004805762,"threshold_uncertainty_score":0.01607692,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02359953387203726,"score_gpt":0.4463642154017388,"score_spread":0.4227646815297015,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}