{"id":"W2057895084","doi":"10.1182/blood-2011-08-375873","title":"Role of SHP2 phosphatase in KIT-induced transformation: identification of SHP2 as a druggable target in diseases involving oncogenic KIT","year":2012,"lang":"en","type":"article","venue":"Blood","topic":"Mast cells and histamine","field":"Immunology and Microbiology","cited_by":54,"is_retracted":false,"has_abstract":true,"ca_institutions":"Queen's University","funders":"National Institute of Diabetes and Digestive and Kidney Diseases; National Cancer Institute; National Heart, Lung, and Blood Institute; School of Medicine, Indiana University","keywords":"Druggability; Cancer research; Protein tyrosine phosphatase; Kinase; Phosphatase; Biology; Leukemia; Tyrosine kinase; Oncogene; Signal transduction; Phosphorylation; Cell biology; Cancer; Immunology; Genetics; Gene; Cell cycle","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002717831,0.0001071413,0.0002587407,0.0001633115,0.0000353519,0.00000449658,0.0001392336,0.0001235211,0.0005792111],"category_scores_gemma":[0.00004513427,0.0001087213,0.00006228725,0.000212064,0.00005389992,0.0002402958,0.00002523075,0.000113767,0.00006958847],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002135094,"about_ca_system_score_gemma":0.0000632984,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007407854,"about_ca_topic_score_gemma":0.0001641538,"domain_scores_codex":[0.9989488,0.00008630974,0.0005361612,0.000136111,0.00004344786,0.0002492371],"domain_scores_gemma":[0.9995052,0.0000467253,0.000180792,0.0002024323,0.00003864531,0.00002618083],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00009732117,0.001665435,0.02311032,0.0001302803,0.00004800888,0.000001264861,0.003943632,0.000007168261,0.9670083,0.002993257,0.00003609511,0.0009589085],"study_design_scores_gemma":[0.002630871,0.00007746282,0.0383548,0.00005169368,0.00007459246,0.000007210888,0.001346284,0.00001422669,0.9549522,0.0002759863,0.002085651,0.0001290538],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9763909,0.02238605,0.000007070425,0.00002637952,0.0001119837,0.0002362392,0.0001265309,0.00001213818,0.0007027193],"genre_scores_gemma":[0.9992041,0.0001244004,0.00002600129,0.00001549118,0.00001455846,0.00003173035,0.0003833985,0.000009083526,0.0001912225],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02281323,"threshold_uncertainty_score":0.6341956,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006741209296627824,"score_gpt":0.2150593281260542,"score_spread":0.2083181188294263,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}