{"id":"W2057925104","doi":"10.1016/j.cbpc.2008.01.008","title":"3-Hydroxy-3-methylglutaryl coenzyme A reductase in rainbow trout: Effects of fasting and statin drugs on activities and mRNA transcripts","year":2008,"lang":"en","type":"article","venue":"Comparative Biochemistry and Physiology Part C Toxicology & Pharmacology","topic":"Aquaculture Nutrition and Growth","field":"Agricultural and Biological Sciences","cited_by":14,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Ottawa; Ontario Genomics","funders":"Pfizer","keywords":"Cerivastatin; Rainbow trout; HMG-CoA reductase; Internal medicine; Endocrinology; Coenzyme A; Statin; Hydroxymethylglutaryl-CoA reductase; Atorvastatin; Reductase; Trout; Lovastatin; Adenylate kinase; Biology; Cholesterol; Pharmacology; Chemistry; Enzyme; Biochemistry; Medicine; Pravastatin; Fish <Actinopterygii>","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000272158,0.0002628942,0.0003774461,0.0004080064,0.0004349544,0.0004054719,0.0002047387,0.0002721928,0.001797988],"category_scores_gemma":[0.0002852407,0.0004641907,0.0006808119,0.0003218775,0.0005978456,0.0004239886,0.0002775032,0.000647772,0.0003959779],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0008505479,"about_ca_system_score_gemma":0.0008226724,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.01272241,"about_ca_topic_score_gemma":0.02279586,"domain_scores_codex":[0.9998281,0.00001657906,0.00001553634,0.0000554273,0.00002724677,0.00005707479],"domain_scores_gemma":[0.9996859,0.00005216978,0.00005344934,0.00003636127,0.00005243754,0.0001196969],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00447692,0.00007634028,0.00418652,0.00005598773,0.00003707745,0.0000960602,0.0001630848,0.0001485881,0.9889103,0.0002585062,0.0001651304,0.001425477],"study_design_scores_gemma":[0.0002970402,0.002522849,0.2488123,0.00001680958,0.0002442203,0.000420492,0.0007629186,0.002594289,0.7413552,0.0002518421,0.002674366,0.00004777317],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9960659,0.0007776326,0.0005986816,0.0001422478,0.00005492866,0.00001685408,0.001318536,0.00003992648,0.000985315],"genre_scores_gemma":[0.9862812,0.0005945761,0.00120737,0.000111214,0.00003197628,0.0000713414,0.002108626,0.00004507839,0.009548593],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01272241,"threshold_uncertainty_score":0.02529669,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02569695269939501,"score_gpt":0.2720073549682648,"score_spread":0.2463104022688698,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}