{"id":"W2057935373","doi":"10.1016/j.ijrobp.2003.09.091","title":"Acquired resistance to EGFR inhibitors: mechanisms and prevention strategies","year":2004,"lang":"en","type":"review","venue":"International Journal of Radiation Oncology*Biology*Physics","topic":"Lung Cancer Treatments and Mutations","field":"Medicine","cited_by":104,"is_retracted":false,"has_abstract":false,"ca_institutions":"Health Sciences Centre; Sunnybrook Health Science Centre; Women's College Hospital; University of Toronto","funders":"","keywords":"Medicine; Clinical trial; EGFR inhibitors; Epidermal growth factor receptor; Drug; Drug resistance; Chemotherapy; Lung cancer; Pharmacology; Combination therapy; Oncology; Cancer; Internal medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0003250737,0.000335068,0.001181123,0.0003052404,0.00007839314,0.00006794972,0.000249153,0.0003939489,0.00003589507],"category_scores_gemma":[0.0001341783,0.0002694011,0.000423842,0.0002199067,0.00009781494,0.0003178565,0.00005990777,0.0003215719,0.00002766387],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001699065,"about_ca_system_score_gemma":0.003356208,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001042719,"about_ca_topic_score_gemma":0.00001102034,"domain_scores_codex":[0.9979461,0.0001799941,0.001047278,0.0003237882,0.0002945107,0.0002082849],"domain_scores_gemma":[0.9973488,0.0001911136,0.001503755,0.0001637223,0.0006069164,0.000185671],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0001293551,0.0003085471,0.00007945162,0.0006706452,0.001938131,0.00007381715,0.0003706089,0.0000437953,0.00004409095,0.04818355,0.0007864966,0.9473715],"study_design_scores_gemma":[0.003316256,0.001398405,0.00008901457,0.007207836,0.002028807,0.0003295045,0.0001244323,0.000004352506,0.00004547378,0.04065198,0.9445356,0.0002683171],"study_design_candidate":"design_other","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0002186037,0.9643018,0.0279025,0.001686977,0.003254435,0.001106006,0.0001619559,0.00005152359,0.001316149],"genre_scores_gemma":[0.003381792,0.9778397,0.01501405,0.0003161977,0.002481005,0.00008335215,0.0003822862,0.0000621639,0.0004394561],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9471032,"threshold_uncertainty_score":0.9999758,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0301652909814909,"score_gpt":0.4060449897394728,"score_spread":0.3758796987579819,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}