{"id":"W2057938810","doi":"10.1186/1479-5876-8-s1-p60","title":"Valproic acid suppresses interleukin-1β-induced microsomal prostaglandin E2 Synthase-1 expression in chondrocytes","year":2010,"lang":"en","type":"article","venue":"Journal of Translational Medicine","topic":"Histone Deacetylase Inhibitors Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal; Hôpital Notre-Dame","funders":"","keywords":"Valproic Acid; Prostaglandin E2; Histone deacetylase; Chemistry; Interleukin; Prostaglandin; Histone deacetylase inhibitor; Microsome; Retinoic acid; Pharmacology; Histone; Biochemistry; Cytokine; Enzyme; Endocrinology; Internal medicine; Medicine; Biology; Epilepsy; Gene; Neuroscience","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001252858,0.0003288908,0.0003697114,0.0001709029,0.000125164,0.0002396889,0.000126288,0.0001637354,0.0007114212],"category_scores_gemma":[0.000132459,0.0001255028,0.0002317196,0.0001178311,0.0002534505,0.0001320629,0.0001381255,0.000470108,0.0001961634],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001693673,"about_ca_system_score_gemma":0.0003323364,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001093912,"about_ca_topic_score_gemma":0.001835991,"domain_scores_codex":[0.9998831,0.00002551436,0.00002224961,0.00001657014,0.00002432562,0.00002820544],"domain_scores_gemma":[0.9998974,0.00001465903,0.00002839171,0.00001235439,0.00001450635,0.00003264825],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001699363,0.0001012352,0.0003670457,0.00009130906,0.00001743856,0.00006183839,0.00003469014,0.00007523022,0.9942199,0.00002226203,0.0000477804,0.0032619],"study_design_scores_gemma":[0.0003002019,0.005507641,0.0123847,0.00001621594,0.00006739439,0.000341697,0.000151063,0.0005989761,0.9778456,0.00005360594,0.002724305,0.000008679756],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.995409,0.003676956,0.000281932,0.0000617101,0.00003177109,0.00001064519,0.0001186588,0.00002785585,0.0003815131],"genre_scores_gemma":[0.9967359,0.001619814,0.0003403495,0.0000444262,0.00001544454,0.00001463585,0.0001914118,0.000008017031,0.001030048],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001093912,"threshold_uncertainty_score":0.002379894,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01355807264132776,"score_gpt":0.3009413511498393,"score_spread":0.2873832785085116,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}