{"id":"W2057946435","doi":"10.1016/j.pupt.2012.05.007","title":"cAMP regulation of airway smooth muscle function","year":2012,"lang":"en","type":"review","venue":"Pulmonary Pharmacology & Therapeutics","topic":"Asthma and respiratory diseases","field":"Medicine","cited_by":242,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Manitoba","funders":"National Heart, Lung, and Blood Institute; Canadian Institutes of Health Research; Ministry of Education, Culture, Sports, Science and Technology","keywords":"Tachyphylaxis; Bronchoconstriction; Medicine; Formoterol; Phosphodiesterase; COPD; Roflumilast; Effector; Intracellular; Pharmacology; Protein kinase A; Contraction (grammar); Agonist; Desensitization (medicine); Asthma; Receptor; Internal medicine; Kinase; Cell biology; Immunology; Biology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004249666,0.001011008,0.001563557,0.001755297,0.000273213,0.0009909661,0.0008706826,0.0009843417,0.004776845],"category_scores_gemma":[0.0004344155,0.000333777,0.0004825175,0.001555794,0.0005601392,0.0009248586,0.0009073698,0.001843211,0.002929681],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004584147,"about_ca_system_score_gemma":0.001029904,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009694023,"about_ca_topic_score_gemma":0.00212203,"domain_scores_codex":[0.9998709,0.00001743354,0.00002036971,0.0000233463,0.00005001955,0.00001788059],"domain_scores_gemma":[0.9998529,0.00005952944,0.00002850985,0.000005477777,0.00003497904,0.00001870797],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0002209105,0.0001169652,0.0001654345,0.02108375,0.0001115533,0.0002886607,0.0000408454,0.0002778189,0.005075152,0.001531832,0.02001972,0.9510673],"study_design_scores_gemma":[0.00008369864,0.0001977897,0.001950362,0.004415368,0.0002918181,0.001188169,0.00007000235,0.0001651939,0.001425816,0.001616826,0.9885653,0.00002975216],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.000140972,0.9980801,0.000133281,0.000193892,0.0001883489,0.000007418178,0.00002579279,0.000008422227,0.001221776],"genre_scores_gemma":[0.000738639,0.9980001,0.0001858736,0.0001324187,0.0002083544,0.000007214149,0.00003421933,0.000001147667,0.0006919312],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.004776845,"threshold_uncertainty_score":0.01598012,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06663339408242841,"score_gpt":0.3550897308609732,"score_spread":0.2884563367785448,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}