{"id":"W2057946453","doi":"10.1053/j.gastro.2009.04.004","title":"E-Cadherin Regulates Metastasis of Pancreatic Cancer In Vivo and Is Suppressed by a SNAIL/HDAC1/HDAC2 Repressor Complex","year":2009,"lang":"en","type":"article","venue":"Gastroenterology","topic":"Histone Deacetylase Inhibitors Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":352,"is_retracted":false,"has_abstract":false,"ca_institutions":"","funders":"Medical Research Council; Deutsche Krebshilfe; Deutsche Forschungsgemeinschaft; Centre in Green Chemistry and Catalysis","keywords":"Pancreatic cancer; Cancer research; Metastasis; Gene silencing; Biology; KRAS; Epithelial–mesenchymal transition; Epigenetics; Cancer; Genetics; Colorectal cancer; Gene","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002171585,0.0003889492,0.000318917,0.0004473866,0.0003430481,0.0006094458,0.0003329174,0.0001710195,0.001905979],"category_scores_gemma":[0.0001405895,0.0004491163,0.0002976811,0.0002688579,0.0003829299,0.0003010506,0.0003882469,0.0007368283,0.0006293836],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007239235,"about_ca_system_score_gemma":0.0003380937,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001467391,"about_ca_topic_score_gemma":0.003388715,"domain_scores_codex":[0.9997249,0.00003301884,0.000022321,0.00004372734,0.00009034912,0.000085733],"domain_scores_gemma":[0.999835,0.00001767518,0.00004054693,0.00002335059,0.00001458864,0.00006886131],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00011573,0.00001466141,0.0002050132,0.00001248327,0.000004790295,0.00002724052,0.000006070894,0.00003367652,0.9989765,0.0001389223,0.00005224589,0.0004127056],"study_design_scores_gemma":[0.00003440051,0.00005894268,0.01074704,0.000002869456,0.00001472815,0.0002141764,0.00002855658,0.001923728,0.9850233,0.00006698242,0.001880438,0.000004884043],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9911177,0.002244569,0.003413422,0.000197348,0.00004111295,0.00001568651,0.0004159056,0.0001978719,0.002356448],"genre_scores_gemma":[0.9941682,0.0005463316,0.0008994991,0.0000386996,0.00001010542,0.00001707719,0.0005916539,0.00004378247,0.003684696],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001905979,"threshold_uncertainty_score":0.006376147,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01219020167058888,"score_gpt":0.2832068394538751,"score_spread":0.2710166377832863,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}