{"id":"W2057984773","doi":"10.1016/j.marenvres.2009.04.002","title":"Up-regulation of hepatic ABCC2, ABCG2, CYP1A1 and GST in multixenobiotic-resistant killifish (Fundulus heteroclitus) from the Sydney Tar Ponds, Nova Scotia, Canada","year":2009,"lang":"en","type":"article","venue":"Marine Environmental Research","topic":"Drug Transport and Resistance Mechanisms","field":"Medicine","cited_by":73,"is_retracted":false,"has_abstract":false,"ca_institutions":"Fisheries and Oceans Canada; Bedford Institute of Oceanography; Cape Breton University; Institute for Marine Biosciences; Dalhousie University","funders":"","keywords":"Killifish; Fundulus; Biology; Multidrug resistance-associated protein 2; Xenobiotic; Cytochrome P450; Population; ATP-binding cassette transporter; Biochemistry; Enzyme; Transporter; Fishery; Fish <Actinopterygii>; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005491964,0.0002195484,0.0003824031,0.0001217691,0.0001219922,0.00003006123,0.0002145169,0.0001043489,0.0007644408],"category_scores_gemma":[0.00006401766,0.0001605669,0.00006206787,0.0002174998,0.0002825053,0.00007985067,0.0001215195,0.0004839735,0.00001189859],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00055807,"about_ca_system_score_gemma":0.0001479013,"about_ca_topic_candidate":true,"about_ca_topic_consensus":true,"about_ca_topic_score_codex":0.2982983,"about_ca_topic_score_gemma":0.6238747,"domain_scores_codex":[0.9972733,0.0001270072,0.0004770621,0.0004401515,0.00116038,0.0005221409],"domain_scores_gemma":[0.9989812,0.0002074648,0.00007483034,0.0005018996,0.00002013685,0.0002144422],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.001587149,0.0007409167,0.7282193,0.0001346123,0.00008824181,0.0002178644,0.0006454468,0.00003901348,0.254414,0.0002559035,0.0005645573,0.013093],"study_design_scores_gemma":[0.001932364,0.000285573,0.9748513,0.0001542705,0.00003207356,0.000005576526,0.0007089761,0.0004783253,0.01990589,0.0003372442,0.001155627,0.0001527663],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9962724,0.0003514333,0.00001705008,0.001620356,0.0001232756,0.000705914,0.0001023986,0.000009333018,0.0007978522],"genre_scores_gemma":[0.9974849,0.0001394883,0.0002131661,0.0002157255,0.00006893215,0.00000607861,0.0003223816,0.00002585376,0.001523522],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.3255765,"threshold_uncertainty_score":0.8370091,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01696562104683578,"score_gpt":0.261539229261769,"score_spread":0.2445736082149333,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}