{"id":"W2057984773","doi":"10.1016/j.marenvres.2009.04.002","title":"Up-regulation of hepatic ABCC2, ABCG2, CYP1A1 and GST in multixenobiotic-resistant killifish (Fundulus heteroclitus) from the Sydney Tar Ponds, Nova Scotia, Canada","year":2009,"lang":"en","type":"article","venue":"Marine Environmental Research","topic":"Drug Transport and Resistance Mechanisms","field":"Medicine","cited_by":73,"is_retracted":false,"has_abstract":false,"ca_institutions":"Fisheries and Oceans Canada; Bedford Institute of Oceanography; Cape Breton University; Institute for Marine Biosciences; Dalhousie University","funders":"","keywords":"Killifish; Fundulus; Biology; Multidrug resistance-associated protein 2; Xenobiotic; Cytochrome P450; Population; ATP-binding cassette transporter; Biochemistry; Enzyme; Transporter; Fishery; Fish <Actinopterygii>; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00007400133,0.0001848076,0.000253008,0.0005296271,0.0005628504,0.0003384713,0.0001905855,0.000228964,0.001157082],"category_scores_gemma":[0.0001740909,0.0001708488,0.0001639642,0.0002743492,0.0003200239,0.0001231365,0.000181241,0.0002805152,0.0001747977],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00190416,"about_ca_system_score_gemma":0.001073734,"about_ca_topic_candidate":true,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.3694149,"about_ca_topic_score_gemma":0.5507753,"domain_scores_codex":[0.9999077,0.000004001877,0.000005077296,0.0000208215,0.00002613704,0.00003621487],"domain_scores_gemma":[0.9998127,0.00001653954,0.00003311287,0.00000906572,0.00007311303,0.00005556744],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.00161059,0.00006692524,0.0752897,0.00005665492,0.00003128096,0.0005115952,0.000495193,0.0001807155,0.9186448,0.00007655343,0.0002345893,0.002801372],"study_design_scores_gemma":[0.0000227846,0.0003155273,0.9466732,0.000005253998,0.00003156652,0.0003509685,0.0008539059,0.0003245741,0.05057189,0.00002148804,0.000819326,0.000009613025],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9992749,0.00008067946,0.00003477043,0.00002019339,0.000002101586,0.000003844206,0.0002264514,0.000002541188,0.0003545097],"genre_scores_gemma":[0.9959388,0.000072975,0.00008483123,0.00002686457,0.000001406175,0.000005071312,0.0004737891,0.000002952811,0.003393324],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.6305851,"threshold_uncertainty_score":0.7345293,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01696562104683578,"score_gpt":0.261539229261769,"score_spread":0.2445736082149333,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}