{"id":"W2058029230","doi":"10.1074/jbc.m114.589408","title":"Structural Basis for Regulation of the Human Acetyl-CoA Thioesterase 12 and Interactions with the Steroidogenic Acute Regulatory Protein-related Lipid Transfer (START) Domain","year":2014,"lang":"en","type":"article","venue":"Journal of Biological Chemistry","topic":"Peroxisome Proliferator-Activated Receptors","field":"Biochemistry, Genetics and Molecular Biology","cited_by":30,"is_retracted":false,"has_abstract":true,"ca_institutions":"Structural Genomics Consortium","funders":"","keywords":"Thioesterase; Biochemistry; Enzyme; Tetramer; Chemistry; Biology; Cell biology; Biosynthesis","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000105323,0.0001876097,0.0001464247,0.00007721036,0.0001298847,0.0001559355,0.0002404642,0.0002596529,0.0006902422],"category_scores_gemma":[0.0001302084,0.0001241918,0.0002097091,0.00007838331,0.0001989369,0.00008611217,0.0001471236,0.0003247676,0.0003676509],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002254621,"about_ca_system_score_gemma":0.0001334176,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004766537,"about_ca_topic_score_gemma":0.0005610377,"domain_scores_codex":[0.999917,0.00001842969,0.000005759548,0.00002256232,0.00002158963,0.00001462883],"domain_scores_gemma":[0.999902,0.0000165232,0.0000364774,0.000007570525,0.00001101266,0.00002645888],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002268792,0.0000501585,0.0008015986,0.0000245739,0.000006803295,0.0002146194,0.00002938053,0.0004623213,0.9964219,0.0003373102,0.0000811357,0.00134329],"study_design_scores_gemma":[0.0001325154,0.000539373,0.03256829,0.00001574293,0.0000343678,0.001584507,0.00008126472,0.01449874,0.9422174,0.0006482929,0.007648882,0.00003060863],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9959438,0.0007879927,0.002360811,0.00008952152,0.00002121146,0.00001113087,0.00007763439,0.00004801861,0.0006598266],"genre_scores_gemma":[0.9979243,0.0001761655,0.001040593,0.0000491206,0.000008052367,0.000009106897,0.000153234,0.000005664986,0.0006337571],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0006902422,"threshold_uncertainty_score":0.002309144,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01107049512193955,"score_gpt":0.2309871907871288,"score_spread":0.2199166956651892,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}