{"id":"W2058036817","doi":"10.1016/j.cellsig.2014.12.012","title":"Acute Wnt pathway activation positively regulates leptin gene expression in mature adipocytes","year":2014,"lang":"en","type":"article","venue":"Cellular Signalling","topic":"Wnt/β-catenin signaling in development and cancer","field":"Biochemistry, Genetics and Molecular Biology","cited_by":32,"is_retracted":false,"has_abstract":false,"ca_institutions":"Lunenfeld-Tanenbaum Research Institute; Mount Sinai Hospital; University Health Network","funders":"Canadian Institutes of Health Research; Canadian HIV Trials Network, Canadian Institutes of Health Research; National Natural Science Foundation of China","keywords":"Wnt signaling pathway; Leptin; Adipogenesis; Endocrinology; Internal medicine; Adipose tissue; Biology; Adipocyte; WNT3A; Cell biology; Signal transduction; Medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003193113,0.0002208102,0.0001807896,0.00007740033,0.000105009,0.00004582347,0.0002111955,0.0002609172,0.00004329261],"category_scores_gemma":[0.00003207831,0.000209206,0.00008163345,0.0001205196,0.00003894432,0.00001180216,0.00008397891,0.0001582336,0.00001375601],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003363008,"about_ca_system_score_gemma":0.00005403547,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000003959701,"about_ca_topic_score_gemma":0.000001822868,"domain_scores_codex":[0.9986912,0.00009565619,0.0002674089,0.000457881,0.0001839695,0.0003038868],"domain_scores_gemma":[0.9995087,0.00002320736,0.000128453,0.0001898442,0.00008182201,0.00006797611],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001185709,0.00002903714,0.000651687,0.00001593647,0.00003610028,0.000005100765,0.0001525348,0.001032344,0.9967285,0.00002721984,0.0001800178,0.001022968],"study_design_scores_gemma":[0.0005073413,0.00007934363,0.0005228374,0.0001359693,0.0000134279,0.00000304225,0.00003448411,0.0003863743,0.9953348,0.0001878571,0.002499176,0.000295353],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9665253,0.0009490105,0.03176888,0.00006567754,0.0001253868,0.0001615457,0.000003466031,0.00002671357,0.0003739723],"genre_scores_gemma":[0.9925178,0.00007818425,0.005581574,0.0001523245,0.0003454373,0.00003295205,0.0003578117,0.0000403432,0.0008935441],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02618731,"threshold_uncertainty_score":0.8531173,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006763031861724836,"score_gpt":0.204054411431367,"score_spread":0.1972913795696421,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}