{"id":"W2058036817","doi":"10.1016/j.cellsig.2014.12.012","title":"Acute Wnt pathway activation positively regulates leptin gene expression in mature adipocytes","year":2014,"lang":"en","type":"article","venue":"Cellular Signalling","topic":"Wnt/β-catenin signaling in development and cancer","field":"Biochemistry, Genetics and Molecular Biology","cited_by":32,"is_retracted":false,"has_abstract":false,"ca_institutions":"Lunenfeld-Tanenbaum Research Institute; Mount Sinai Hospital; University Health Network","funders":"Canadian Institutes of Health Research; Canadian HIV Trials Network, Canadian Institutes of Health Research; National Natural Science Foundation of China","keywords":"Wnt signaling pathway; Leptin; Adipogenesis; Endocrinology; Internal medicine; Adipose tissue; Biology; Adipocyte; WNT3A; Cell biology; Signal transduction; Medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001590928,0.0002490228,0.0003105486,0.0003422383,0.0002264279,0.0006967348,0.0001229634,0.0002278927,0.002247623],"category_scores_gemma":[0.0001672725,0.0002910849,0.0003379989,0.0002575372,0.0003539476,0.0003374665,0.0003730808,0.0008052445,0.0005068938],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000344739,"about_ca_system_score_gemma":0.0002772456,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007114392,"about_ca_topic_score_gemma":0.001716494,"domain_scores_codex":[0.9997762,0.00002869738,0.00002038309,0.00004407692,0.00005145032,0.00007922844],"domain_scores_gemma":[0.9998525,0.00003416665,0.00003193067,0.00001563035,0.00001751919,0.00004814132],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003688342,0.00001060231,0.0002895515,0.00002209266,0.000003255723,0.00006506326,0.00001934332,0.00001124685,0.9984558,0.0001015281,0.00003232055,0.000620362],"study_design_scores_gemma":[0.00005901963,0.0002272204,0.02693024,0.00001698257,0.00002708088,0.0004049467,0.0002212362,0.0003770302,0.9682845,0.0001881629,0.003254858,0.000008727149],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9911617,0.003703292,0.002379245,0.0001871275,0.00006888135,0.00002261221,0.0006799286,0.00006182015,0.001735405],"genre_scores_gemma":[0.9895895,0.001927801,0.00146286,0.0001385657,0.00002982801,0.00005091419,0.0009103288,0.00004252446,0.005847702],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002247623,"threshold_uncertainty_score":0.007519066,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006763031861724836,"score_gpt":0.204054411431367,"score_spread":0.1972913795696421,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}