{"id":"W2058067127","doi":"10.1016/s0969-9961(03)00035-4","title":"Presenilin-1 interacts directly with the β-site amyloid protein precursor cleaving enzyme (BACE1)","year":2003,"lang":"en","type":"article","venue":"Neurobiology of Disease","topic":"Alzheimer's disease research and treatments","field":"Medicine","cited_by":40,"is_retracted":false,"has_abstract":false,"ca_institutions":"Université Laval; Hôpital Saint-François d'Assise","funders":"Fonds de Recherche du Québec - Santé; Canadian Institutes of Health Research","keywords":"Presenilin; Amyloid precursor protein; Colocalization; Amyloid precursor protein secretase; BACE1-AS; Gamma secretase; Chemistry; Immunoprecipitation; Enzyme; Cell biology; Biochemistry; Amyloid (mycology); Alzheimer's disease; Biology; Genetically modified mouse; Transgene; Medicine; Disease; Gene; Pathology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003080598,0.0004733284,0.0003576713,0.0005645343,0.0006076649,0.0009633518,0.0003403067,0.0006445447,0.002624508],"category_scores_gemma":[0.0007511639,0.0003869595,0.0002953691,0.0002148294,0.0002221307,0.0006384474,0.0006252298,0.0007117816,0.001967777],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0009449625,"about_ca_system_score_gemma":0.0002083506,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009395964,"about_ca_topic_score_gemma":0.001426629,"domain_scores_codex":[0.9996936,0.00005215954,0.00001596271,0.00007050337,0.00008208289,0.0000857031],"domain_scores_gemma":[0.9997978,0.00004854188,0.00005449913,0.00001532653,0.00003215943,0.00005177605],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002494012,0.00005794155,0.001507195,0.0001104939,0.00005132328,0.0006194972,0.00007639209,0.00008210257,0.9921499,0.0005281327,0.0007065939,0.003860931],"study_design_scores_gemma":[0.00005703856,0.0001375123,0.02156078,0.00002522122,0.00004512569,0.003726545,0.0001188352,0.001376056,0.9577193,0.000383553,0.01482912,0.00002091032],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9824377,0.01016345,0.001948681,0.0004701597,0.0001203153,0.00003049449,0.0001617589,0.00007351524,0.004594012],"genre_scores_gemma":[0.9874978,0.002789576,0.001754555,0.0003179193,0.00005802221,0.00002610402,0.000752055,0.00001898476,0.006784923],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002624508,"threshold_uncertainty_score":0.008779883,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01548934281665538,"score_gpt":0.2748951036265215,"score_spread":0.2594057608098661,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}