{"id":"W2058157760","doi":"10.1139/v10-149","title":"Towards the development of new subtype-specific muscarinic receptor radiopharmaceuticals — Radiosynthesis and ex vivo biodistribution of [<sup>18</sup>F]3-(4-(2-(2-(2-fluoroethoxy)ethoxy)ethylthio)-1,2,5-thiadiazol-3-yl)-1-methyl-1,2,5,6-tetrahydropyridine","year":2010,"lang":"en","type":"article","venue":"Canadian Journal of Chemistry","topic":"Receptor Mechanisms and Signaling","field":"Biochemistry, Genetics and Molecular Biology","cited_by":5,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; Centre for Addiction and Mental Health","funders":"Ontario Ministry of Research and Innovation; University of North Carolina at Chapel Hill","keywords":"Radiosynthesis; Biodistribution; Chemistry; Muscarinic acetylcholine receptor; In vivo; Ex vivo; Radioligand; Radiochemistry; In vitro; Receptor; Pharmacology; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":true,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003865969,0.0004897019,0.0003993539,0.0001898497,0.0001253356,0.0003051132,0.0006295326,0.0004675336,0.001009179],"category_scores_gemma":[0.0002977392,0.0003146638,0.00029397,0.000141095,0.0002619669,0.0003511074,0.0002155512,0.0006867704,0.0005252969],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004691088,"about_ca_system_score_gemma":0.0002335624,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007202977,"about_ca_topic_score_gemma":0.001021807,"domain_scores_codex":[0.9998814,0.00002906231,0.00000906459,0.00003396954,0.00002331577,0.00002309126],"domain_scores_gemma":[0.9998468,0.00003829305,0.00004815789,0.00002045081,0.00002785119,0.00001833445],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00006789472,0.0000126794,0.00003466609,0.00004508496,0.000006474806,0.00002934011,0.00001334604,0.0001263451,0.9978566,0.0001015183,0.00002267529,0.001683502],"study_design_scores_gemma":[0.00002419624,0.0005115684,0.0004727597,0.000003605068,0.00002954576,0.00022299,0.000008221896,0.0004942784,0.9955591,0.00002309266,0.002644051,0.000006501859],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9412516,0.006353206,0.04819833,0.000172267,0.00004789997,0.0003005577,0.0005909742,0.0003400368,0.002745093],"genre_scores_gemma":[0.913467,0.005547198,0.07371361,0.000177921,0.00004498006,0.0003091627,0.001208109,0.000109537,0.005422471],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001009179,"threshold_uncertainty_score":0.003403604,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02576388714074258,"score_gpt":0.2551673676315249,"score_spread":0.2294034804907823,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}