{"id":"W2058182298","doi":"10.1074/jbc.m109.059162","title":"Crystal Structures of Progressive Ca2+ Binding States of the Ca2+ Sensor Ca2+ Binding Domain 1 (CBD1) from the CALX Na+/Ca2+ Exchanger Reveal Incremental Conformational Transitions","year":2009,"lang":"en","type":"article","venue":"Journal of Biological Chemistry","topic":"Plant Stress Responses and Tolerance","field":"Agricultural and Biological Sciences","cited_by":40,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Manitoba; St. Boniface Hospital","funders":"Canadian Institutes of Health Research","keywords":"Sodium-calcium exchanger; Crystallography; Allosteric regulation; Binding site; Chemistry; Biophysics; Mutagenesis; Crystal structure; Protein structure; Stereochemistry; Calcium; Biochemistry; Mutation; Biology; Receptor","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001730831,0.0005042566,0.0004967393,0.0001897176,0.000546565,0.0008498341,0.0007201864,0.0007736598,0.0009790484],"category_scores_gemma":[0.0004128864,0.0003605072,0.0003533079,0.0003074967,0.0004732772,0.0005207269,0.0003899377,0.002045781,0.0002039624],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001053128,"about_ca_system_score_gemma":0.0004933317,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.003263326,"about_ca_topic_score_gemma":0.004038762,"domain_scores_codex":[0.9998865,0.000008691508,0.000007138805,0.00003350145,0.00004340738,0.00002078643],"domain_scores_gemma":[0.9998267,0.00003846522,0.00004666626,0.000008137912,0.0000309795,0.00004895589],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.002078766,0.0007824095,0.02416626,0.0009419178,0.0002694872,0.002047947,0.001223169,0.01142658,0.913937,0.006182709,0.01144961,0.02549417],"study_design_scores_gemma":[0.001606995,0.001090994,0.1380221,0.000154419,0.0005104932,0.004556935,0.001629332,0.1062941,0.6888164,0.005493865,0.05148523,0.0003391941],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9902019,0.003323582,0.002259093,0.0006109354,0.00008064867,0.00003777513,0.001288076,0.0001635404,0.002034551],"genre_scores_gemma":[0.9840103,0.002019798,0.005789764,0.0003403375,0.00002396011,0.00005045324,0.005766823,0.00003798925,0.001960555],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003263326,"threshold_uncertainty_score":0.007641017,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01993045214778543,"score_gpt":0.2343168840236394,"score_spread":0.214386431875854,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}