{"id":"W2058200943","doi":"10.1021/ml200129s","title":"Mannitol Bis-phosphate Based Inhibitors of Fructose 1,6-Bisphosphate Aldolases","year":2011,"lang":"en","type":"article","venue":"ACS Medicinal Chemistry Letters","topic":"Carbohydrate Chemistry and Synthesis","field":"Chemistry","cited_by":12,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal","funders":"","keywords":"Moiety; Chemistry; Alkyl; Biochemistry; Fructose; Mannitol; Substrate (aquarium); Enzyme; Phosphate; Selectivity; Stereochemistry; Combinatorial chemistry; Biology; Organic chemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.0002411187,0.0005644719,0.0006889155,0.00005029924,0.0001158894,0.00002086987,0.0007256795,0.0003160338,0.005130575],"category_scores_gemma":[0.0002328153,0.00055266,0.000301783,0.0003063087,0.0005983623,0.0001510694,0.0001074424,0.0005022532,0.00002326526],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001133511,"about_ca_system_score_gemma":0.0001382265,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002259856,"about_ca_topic_score_gemma":0.00000138928,"domain_scores_codex":[0.997063,0.00001957604,0.0008384479,0.0006936298,0.0007066602,0.0006787087],"domain_scores_gemma":[0.9978388,0.0002176986,0.0004774887,0.0009513033,0.000126906,0.0003877835],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002841876,0.0001433668,0.004944816,0.001119445,0.0001328831,0.0004377055,0.0002789708,0.0000121217,0.9889213,0.000003295003,0.002972314,0.0007496103],"study_design_scores_gemma":[0.001036442,0.0000136567,0.0002142221,0.0005117201,0.0002054253,0.00005699334,0.0005659274,0.00003638181,0.9949606,0.00002235104,0.001832312,0.0005439454],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9792584,0.0004940218,0.00004436463,0.0005176212,0.0001755507,0.00007203541,0.00007114344,0.0001736744,0.01919322],"genre_scores_gemma":[0.9978603,0.00004479328,0.0003206917,0.0005514666,0.0004678393,0.00004439729,0.0001055662,0.00007540933,0.0005295275],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01866369,"threshold_uncertainty_score":0.9996925,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01900723574756972,"score_gpt":0.206512825786278,"score_spread":0.1875055900387083,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}