{"id":"W2058224700","doi":"10.1038/sj.bjp.0705281","title":"Dihydropyridine Ca<sup>2+</sup> channel antagonists and agonists block Kv4.2, Kv4.3 and Kv1.4 K<sup>+</sup> channels expressed in HEK293 cells","year":2003,"lang":"en","type":"article","venue":"British Journal of Pharmacology","topic":"Cardiac electrophysiology and arrhythmias","field":"Medicine","cited_by":39,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Calgary","funders":"Japan Society for the Promotion of Science; Japan Health Sciences Foundation; Heart and Stroke Foundation of Canada","keywords":"Nicardipine; HEK 293 cells; Dihydropyridine; Agonist; Biophysics; Chemistry; Antagonist; Potassium channel; Nifedipine; Electrophysiology; Potassium channel blocker; Internal medicine; Biology; Calcium; Biochemistry; Receptor; Medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001799892,0.0002850091,0.0004961814,0.0001493661,0.0001309168,0.0003755795,0.0004535777,0.0002802642,0.001477987],"category_scores_gemma":[0.0002138519,0.0002006197,0.0004016573,0.0001939948,0.0002307935,0.0002479207,0.0001450144,0.0006955496,0.0007512226],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003724523,"about_ca_system_score_gemma":0.0002209777,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006936577,"about_ca_topic_score_gemma":0.001421517,"domain_scores_codex":[0.999721,0.00003510528,0.00004127074,0.00004569719,0.00008642758,0.00007056671],"domain_scores_gemma":[0.9998789,0.00002959316,0.00004346596,0.00001608191,0.00001841263,0.00001360531],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001005665,0.00001745501,0.0001971416,0.00007361242,0.000009831177,0.00006408166,0.00001308801,0.00005445219,0.9978616,0.00008106244,0.0000910823,0.001436037],"study_design_scores_gemma":[0.00004246972,0.0003431182,0.005098985,0.000009197256,0.00004493459,0.0005154976,0.00001881969,0.0007717332,0.9891407,0.00005259742,0.003954103,0.000007801538],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9684739,0.01065146,0.01314662,0.0002725644,0.0001300785,0.0001479688,0.001451337,0.000567335,0.0051587],"genre_scores_gemma":[0.9692607,0.009658865,0.01479311,0.0002613576,0.00008271058,0.0002480079,0.001598398,0.0000951266,0.004001664],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001477987,"threshold_uncertainty_score":0.004944384,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008669646423414848,"score_gpt":0.2593554465871731,"score_spread":0.2506858001637582,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}