{"id":"W2058229884","doi":"10.1002/jps.21954","title":"Biowaiver monographs for immediate release solid oral dosage forms: Doxycycline hyclate**A project of the International Pharmaceutical Federation (FIP), BCS and Biowaiver, www.fip.org/bcs.**This article reflects the scientific opinion of the authors and not the policies of regulating agencies, the International Pharmaceutical Federation (FIP) and the World Health Organization (WHO).","year":2009,"lang":"en","type":"review","venue":"Journal of Pharmaceutical Sciences","topic":"Drug Solubulity and Delivery Systems","field":"Pharmacology, Toxicology and Pharmaceutics","cited_by":42,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Saskatchewan","funders":"Rijksinstituut voor Volksgezondheid en Milieu","keywords":"Bioequivalence; Biopharmaceutics Classification System; Dosage form; Active ingredient; Doxycycline; Dissolution testing; Biopharmaceutical; Pharmacology; Biopharmaceutics; Drug; Immediate release; Medicine; Chemistry; Pharmacokinetics; Antibiotics; Biotechnology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["sts"],"consensus_categories":["sts"],"category_scores_codex":[0.01173974,0.0004464854,0.0009432636,0.000296137,0.002722666,0.0005163256,0.001561123,0.0002604399,0.00006146391],"category_scores_gemma":[0.001248987,0.0001822614,0.0004364336,0.001587457,0.006320998,0.0005452849,0.0005694876,0.001510376,0.000001175983],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001859819,"about_ca_system_score_gemma":0.0009646486,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00006896543,"about_ca_topic_score_gemma":0.0001092131,"domain_scores_codex":[0.9931949,0.002363829,0.002057742,0.0004886094,0.001339402,0.0005554519],"domain_scores_gemma":[0.9931996,0.003147205,0.002461364,0.0002925007,0.0006875232,0.0002117799],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.005089829,0.001633131,0.007822569,0.006131629,0.003831215,0.000008469611,0.02281788,0.001425877,0.01997562,0.07997946,0.02392389,0.8273605],"study_design_scores_gemma":[0.006146668,0.0004667606,0.001327313,0.002595377,0.002508195,0.0003785818,0.002591684,0.1386791,0.02285838,0.001338652,0.8204952,0.0006140678],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"empirical","genre_scores_codex":[0.2282191,0.6073534,0.0005593497,0.1408211,0.01257272,0.009136414,0.0007327386,0.00005445641,0.0005506572],"genre_scores_gemma":[0.6111559,0.3840984,0.0001732217,0.003288309,0.0008745814,0.000045792,0.00002495505,0.00003196486,0.0003067734],"genre_candidate":"review","genre_consensus":null,"teacher_disagreement_score":0.8267463,"threshold_uncertainty_score":0.9985756,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.2486690687547004,"score_gpt":0.5131457547733707,"score_spread":0.2644766860186702,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}