{"id":"W2058229884","doi":"10.1002/jps.21954","title":"Biowaiver monographs for immediate release solid oral dosage forms: Doxycycline hyclate**A project of the International Pharmaceutical Federation (FIP), BCS and Biowaiver, www.fip.org/bcs.**This article reflects the scientific opinion of the authors and not the policies of regulating agencies, the International Pharmaceutical Federation (FIP) and the World Health Organization (WHO).","year":2009,"lang":"en","type":"review","venue":"Journal of Pharmaceutical Sciences","topic":"Drug Solubulity and Delivery Systems","field":"Pharmacology, Toxicology and Pharmaceutics","cited_by":42,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Saskatchewan","funders":"Rijksinstituut voor Volksgezondheid en Milieu","keywords":"Bioequivalence; Biopharmaceutics Classification System; Dosage form; Active ingredient; Doxycycline; Dissolution testing; Biopharmaceutical; Pharmacology; Biopharmaceutics; Drug; Immediate release; Medicine; Chemistry; Pharmacokinetics; Antibiotics; Biotechnology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006231132,0.0008500374,0.0007615065,0.002952404,0.0003165045,0.0005281896,0.0009122195,0.001045696,0.01172452],"category_scores_gemma":[0.0005898469,0.0003196342,0.0003277392,0.001936684,0.000399783,0.0008345899,0.0004996086,0.001594807,0.0119847],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004059709,"about_ca_system_score_gemma":0.00116837,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001355814,"about_ca_topic_score_gemma":0.003256377,"domain_scores_codex":[0.9996903,0.0000383074,0.00004797119,0.00002838079,0.0001774407,0.00001762575],"domain_scores_gemma":[0.999541,0.0001433399,0.0001036442,0.00002106415,0.0001484056,0.00004250885],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00007805688,0.0001593687,0.00005587178,0.00495756,0.00001240825,0.0001710233,0.00004960807,0.0001733799,0.009762017,0.002628951,0.08483998,0.8971117],"study_design_scores_gemma":[0.0000185289,0.00008176393,0.0004838925,0.0004427641,0.00001062952,0.0008421069,0.00001213582,0.00005051286,0.00215968,0.0003480165,0.9955432,0.000006805124],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.002002913,0.9547981,0.004439461,0.002183329,0.00246431,0.0003033028,0.0006809123,0.0002204593,0.03290713],"genre_scores_gemma":[0.007059512,0.9107829,0.00629563,0.001438859,0.0008462426,0.0002886445,0.001398173,0.00006243912,0.07182757],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.01172452,"threshold_uncertainty_score":0.03922236,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.2486690687547004,"score_gpt":0.5131457547733707,"score_spread":0.2644766860186702,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}