{"id":"W2058295402","doi":"10.1074/jbc.m513629200","title":"Regulation of FOXC1 Stability and Transcriptional Activity by an Epidermal Growth Factor-activated Mitogen-activated Protein Kinase Signaling Cascade","year":2006,"lang":"en","type":"article","venue":"Journal of Biological Chemistry","topic":"FOXO transcription factor regulation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":55,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"","keywords":"Transactivation; Transcription factor; Cell biology; Protein kinase A; Ubiquitin; Biology; Phosphorylation; Epidermal growth factor; Biochemistry; Gene; Receptor","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002644339,0.0002213609,0.0003100991,0.00002874313,0.00006843016,0.00002035014,0.0001326174,0.0004120844,0.0001081189],"category_scores_gemma":[0.0001149601,0.0001834994,0.0001621284,0.00009831586,0.0002253941,0.00004437477,0.00001815014,0.0002304001,1.373241e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00005249914,"about_ca_system_score_gemma":0.00006195917,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00004429491,"about_ca_topic_score_gemma":0.000002086365,"domain_scores_codex":[0.9985176,0.0001738958,0.0005514265,0.0003118868,0.0002431486,0.0002020812],"domain_scores_gemma":[0.9988862,0.00002685438,0.0004963576,0.0001475819,0.0003141607,0.0001287893],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001001257,0.0002966278,0.00438081,0.0000572051,0.00004466038,0.000001238755,0.00001973949,0.00003759253,0.9938781,0.000007761174,0.00002497775,0.0002500719],"study_design_scores_gemma":[0.0008417919,0.0002949651,0.08554451,0.00002250265,0.00001515705,0.00003056926,0.00002487261,0.00002896399,0.9127247,0.0001299347,0.0001621092,0.0001799794],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.99758,0.0003096892,0.00162782,0.00008989705,0.00004152038,0.0001574644,0.0001569374,0.00001221476,0.00002446461],"genre_scores_gemma":[0.9991152,0.0000154544,0.0003798107,0.00001011714,0.0001651962,0.000004050918,0.0002704728,0.00001370038,0.00002600005],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0811637,"threshold_uncertainty_score":0.7482887,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02492564284567184,"score_gpt":0.2429413676949844,"score_spread":0.2180157248493125,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}