{"id":"W2058338716","doi":"10.1016/j.ajpath.2014.05.024","title":"Retinal and Nonocular Abnormalities in Cyp27a1Cyp46a1 Mice with Dysfunctional Metabolism of Cholesterol","year":2014,"lang":"en","type":"article","venue":"American Journal Of Pathology","topic":"Cholesterol and Lipid Metabolism","field":"Medicine","cited_by":55,"is_retracted":false,"has_abstract":false,"ca_institutions":"","funders":"National Eye Institute; National Institutes of Health; Foundation Fighting Blindness; Ohio Lions Eye Research Foundation; Research to Prevent Blindness","keywords":"Retina; Retinal; Biology; CYP27A1; Cholesterol; Retinal degeneration; Endocrinology; Retinal pigment epithelium; Internal medicine; Lipid metabolism; Biochemistry; Medicine","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003743973,0.001372311,0.0006369405,0.003224802,0.0008124387,0.0007767492,0.000599946,0.001334743,0.007648186],"category_scores_gemma":[0.0005448839,0.0006723531,0.0007826475,0.0009179386,0.001526117,0.0008316914,0.0006274673,0.00204054,0.00089459],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0009096109,"about_ca_system_score_gemma":0.0006829454,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.003212025,"about_ca_topic_score_gemma":0.003997067,"domain_scores_codex":[0.9991467,0.00006541324,0.00009074301,0.0002953754,0.0002500871,0.0001516187],"domain_scores_gemma":[0.9985179,0.0001661327,0.0006630355,0.0001539744,0.0001153059,0.0003836601],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001492996,0.0003093872,0.001522408,0.000120595,0.00006083706,0.003213798,0.000111974,0.0003755816,0.9867639,0.001624575,0.0006779555,0.003726089],"study_design_scores_gemma":[0.0005439294,0.0009365935,0.07334806,0.0000827217,0.0003577518,0.02021211,0.0005401494,0.004348502,0.8922889,0.001856754,0.00538399,0.0001004719],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9819011,0.001445916,0.004835398,0.0007202416,0.0001858245,0.0001115202,0.004540541,0.000738349,0.005520968],"genre_scores_gemma":[0.9798462,0.001047064,0.003264229,0.000224053,0.00004668331,0.0001261214,0.00140985,0.0003446585,0.01369113],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.007648186,"threshold_uncertainty_score":0.02558577,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.005258839227281029,"score_gpt":0.2251283746473646,"score_spread":0.2198695354200835,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}