{"id":"W2058344326","doi":"10.1158/0008-5472.can-05-1986","title":"<i>Pten</i> Deficiency Activates Distinct Downstream Signaling Pathways in a Tissue-Specific Manner","year":2006,"lang":"en","type":"article","venue":"Cancer Research","topic":"PI3K/AKT/mTOR signaling in cancer","field":"Biochemistry, Genetics and Molecular Biology","cited_by":63,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"York University; National Cancer Institute; Washington University in St. Louis; National Institutes of Health; Harvard University; U.S. Department of Defense","keywords":"PTEN; Cancer research; Carcinogenesis; Protein kinase B; Biology; Prostate; PI3K/AKT/mTOR pathway; Signal transduction; Epithelium; Prostate cancer; Hyperplasia; Tumor suppressor gene; Cancer; Cell biology; Endocrinology; Genetics","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0007447509,0.0002265853,0.000209445,0.0001822773,0.0001980432,0.00009185235,0.0005125036,0.000205698,0.0003024095],"category_scores_gemma":[0.00007099152,0.0002142795,0.00007294185,0.0005735856,0.0002933416,0.00001051016,0.0002084916,0.0004234281,0.00006580679],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000237239,"about_ca_system_score_gemma":0.0003079289,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009104964,"about_ca_topic_score_gemma":0.0004195615,"domain_scores_codex":[0.997297,0.0001786487,0.0003212068,0.0007574937,0.0005636856,0.0008819687],"domain_scores_gemma":[0.9989716,0.00007511684,0.00006594731,0.0005273039,0.0002491922,0.0001108645],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001431515,0.0001130265,0.00511344,0.00003939471,0.000007753438,0.00003243415,0.0000490161,0.0006961512,0.9777928,0.0001964268,0.009111505,0.006704924],"study_design_scores_gemma":[0.0005688808,0.0001684231,0.001668003,0.0000869245,0.000003219783,0.000006378647,0.00008973054,0.00002027413,0.8910966,0.0005149934,0.1054968,0.0002798474],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9829214,0.009878901,0.0002724754,0.0001764259,0.0002027934,0.0003501504,0.00007324434,0.00002709077,0.006097585],"genre_scores_gemma":[0.9968893,0.0004073957,0.0001554627,0.00004253888,0.0008695243,0.0003108641,0.00009518799,0.0000551769,0.00117454],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.09638526,"threshold_uncertainty_score":0.8738063,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04872348623038871,"score_gpt":0.3425641450293687,"score_spread":0.29384065879898,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}