{"id":"W2058369914","doi":"10.1016/j.molbiopara.2006.02.015","title":"Leishmania donovani singly deficient in HGPRT, APRT or XPRT are viable in vitro and within mammalian macrophages","year":2006,"lang":"en","type":"article","venue":"Molecular and Biochemical Parasitology","topic":"Biochemical and Molecular Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":34,"is_retracted":false,"has_abstract":false,"ca_institutions":"","funders":"National Institute of Allergy and Infectious Diseases; National Institutes of Health; Faculty of Medicine, McGill University; McGill University","keywords":"Hypoxanthine-guanine phosphoribosyltransferase; Biology; Adenine phosphoribosyltransferase; Phosphoribosyltransferase; Hypoxanthine Phosphoribosyltransferase; Leishmania donovani; Amastigote; Purine; Biochemistry; Axenic; Hypoxanthine; Leishmania; Molecular biology; Mutant; Enzyme; Genetics; Gene; Leishmaniasis; Visceral leishmaniasis; Parasite hosting","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000370649,0.0006457671,0.0007979418,0.0005785663,0.0003737997,0.001037774,0.0006564498,0.0009300374,0.002931673],"category_scores_gemma":[0.000281894,0.0004890204,0.000377655,0.0002942603,0.0006180828,0.000565252,0.0009389883,0.00166745,0.001580149],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003903742,"about_ca_system_score_gemma":0.0002919211,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007425124,"about_ca_topic_score_gemma":0.001401315,"domain_scores_codex":[0.9992865,0.0001170811,0.0000504485,0.0001241916,0.0002077736,0.0002140961],"domain_scores_gemma":[0.9993222,0.0001822877,0.0001422416,0.0001356626,0.00007483177,0.00014284],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000258785,0.00005608864,0.0001847043,0.00005272554,0.0000122683,0.000158568,0.00007451706,0.00007474981,0.9977394,0.0004971129,0.00009980551,0.0007912045],"study_design_scores_gemma":[0.00004374527,0.0005652403,0.002116481,0.00001456414,0.00002791763,0.0007296805,0.0001254851,0.0005929043,0.9923746,0.0001763345,0.003222346,0.00001075149],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9864413,0.002057894,0.005568994,0.0002925425,0.0001427831,0.00007706017,0.001187451,0.0002742174,0.003957832],"genre_scores_gemma":[0.9789251,0.0007066161,0.004191084,0.0001182118,0.00003510447,0.0001114617,0.002276288,0.0001633728,0.0134728],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002931673,"threshold_uncertainty_score":0.009807467,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007629304554124388,"score_gpt":0.2650985897665634,"score_spread":0.257469285212439,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}