{"id":"W2058369914","doi":"10.1016/j.molbiopara.2006.02.015","title":"Leishmania donovani singly deficient in HGPRT, APRT or XPRT are viable in vitro and within mammalian macrophages","year":2006,"lang":"en","type":"article","venue":"Molecular and Biochemical Parasitology","topic":"Biochemical and Molecular Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":34,"is_retracted":false,"has_abstract":false,"ca_institutions":"","funders":"National Institute of Allergy and Infectious Diseases; National Institutes of Health; Faculty of Medicine, McGill University; McGill University","keywords":"Hypoxanthine-guanine phosphoribosyltransferase; Biology; Adenine phosphoribosyltransferase; Phosphoribosyltransferase; Hypoxanthine Phosphoribosyltransferase; Leishmania donovani; Amastigote; Purine; Biochemistry; Axenic; Hypoxanthine; Leishmania; Molecular biology; Mutant; Enzyme; Genetics; Gene; Leishmaniasis; Visceral leishmaniasis; Parasite hosting","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0002325656,0.0003409788,0.0004141658,0.0001550056,0.00006120032,0.00005257486,0.0002314514,0.0005231612,0.00001225742],"category_scores_gemma":[0.00009699858,0.0002983603,0.00007540724,0.0002981909,0.000423388,0.000006234232,0.0003192039,0.0003409705,0.000004802224],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003368978,"about_ca_system_score_gemma":0.00006080617,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003388168,"about_ca_topic_score_gemma":0.0002268194,"domain_scores_codex":[0.9976366,0.0001270992,0.0004405498,0.0009227457,0.0001922326,0.0006807635],"domain_scores_gemma":[0.9993395,0.00002283669,0.00008833887,0.0003290091,0.00005353735,0.0001667651],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0007955496,0.0002355824,0.0120333,0.00007296506,0.00001589862,0.0004540793,0.00001178189,0.00001210942,0.9855157,0.0001185133,0.000345392,0.0003891126],"study_design_scores_gemma":[0.001497343,0.0002018118,0.006422598,0.00003136261,0.00001412803,0.0002770288,0.00004583106,0.00009003538,0.9891806,0.0003949384,0.001451027,0.0003933077],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9939457,0.004441164,0.0003059391,0.0005159969,0.00005581415,0.000311058,0.00002008838,0.0000148486,0.0003894207],"genre_scores_gemma":[0.9977089,0.00008044706,0.001173628,0.0004969448,0.00006494885,0.00004704651,0.0001576108,0.00003557111,0.0002349289],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.005610706,"threshold_uncertainty_score":0.9999468,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007629304554124388,"score_gpt":0.2650985897665634,"score_spread":0.257469285212439,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}