{"id":"W2058381701","doi":"10.1016/j.bmcl.2010.02.036","title":"Design and optimization of a substituted amino propanamide series of renin inhibitors for the treatment of hypertension","year":2010,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"Renin-Angiotensin System Studies","field":"Medicine","cited_by":17,"is_retracted":false,"has_abstract":false,"ca_institutions":"Merck Canada Inc. (Canada)","funders":"","keywords":"Renin inhibitor; Chemistry; Bioavailability; In vivo; In vitro; Renin–angiotensin system; Pharmacology; Covalent bond; Enzyme inhibitor; Combinatorial chemistry; Biochemistry; Internal medicine; Organic chemistry; Medicine; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001929627,0.0001739719,0.000515379,0.00003801596,0.0000494903,0.00000253286,0.00006375217,0.00009451633,0.00001010149],"category_scores_gemma":[0.0002596005,0.0001041582,0.00007896445,0.0001552658,0.0005369885,0.00002857199,0.00001532928,0.00006820592,1.166825e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003578381,"about_ca_system_score_gemma":0.00007802033,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00005683572,"about_ca_topic_score_gemma":0.000002189812,"domain_scores_codex":[0.9989402,0.00001845132,0.0004443191,0.0002022097,0.000253419,0.0001414496],"domain_scores_gemma":[0.9988745,0.0002173134,0.0003161966,0.0002904543,0.0002449017,0.00005664895],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004821802,0.00008666782,0.002490212,0.0002071676,0.0002099875,0.000008649104,0.0006127119,0.00006039994,0.994961,0.000001262882,0.0003409044,0.0005388734],"study_design_scores_gemma":[0.001783481,0.0003506009,0.005224796,0.0002440167,0.0005957345,0.0001993349,0.0002211833,0.0007711839,0.9904221,9.741011e-7,0.0001059205,0.00008067639],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9888141,0.0009247879,0.005393243,0.003928064,0.0001463104,0.0007629678,0.000006845772,0.00001705447,0.000006600916],"genre_scores_gemma":[0.9907383,0.0002029692,0.008756268,0.00003653074,0.0001723853,0.00002373938,0.00001601594,0.00001984746,0.00003395522],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004538886,"threshold_uncertainty_score":0.4247449,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02654522139390861,"score_gpt":0.2302602202429869,"score_spread":0.2037149988490783,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}