{"id":"W2058426499","doi":"10.1002/syn.10221","title":"Anesthetics inhibit high‐affinity states of dopamine D2 and other G‐linked receptors","year":2003,"lang":"en","type":"article","venue":"Synapse","topic":"Anesthesia and Sedative Agents","field":"Medicine","cited_by":69,"is_retracted":false,"has_abstract":true,"ca_institutions":"Centre for Addiction and Mental Health; University of Toronto","funders":"","keywords":"Chemistry; Receptor; Halothane; Pharmacology; Isoflurane; Dopamine; Stimulation; Dopamine receptor D2; Dopamine receptor; 5-HT receptor; D2-like receptor; Serotonin; Internal medicine; Biochemistry; Biology; Medicine; Dopamine receptor D1","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001524396,0.0003038412,0.0001909748,0.0001476859,0.0001066693,0.0002007291,0.0001530334,0.0001873435,0.001623016],"category_scores_gemma":[0.0003001882,0.0001099507,0.0002340608,0.00009281335,0.000162008,0.0001771516,0.0001506116,0.0003885988,0.000249683],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002077088,"about_ca_system_score_gemma":0.0001825745,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007481863,"about_ca_topic_score_gemma":0.001661759,"domain_scores_codex":[0.9998857,0.00002480433,0.00001063082,0.000009210115,0.00002457326,0.00004517672],"domain_scores_gemma":[0.9998296,0.0000618402,0.00004817815,0.00001655245,0.00002098592,0.0000228161],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000522539,0.00008202591,0.0005445223,0.000116128,0.00001862628,0.00006237418,0.00002810006,0.00007117935,0.9928395,0.0003419911,0.00009131507,0.00528173],"study_design_scores_gemma":[0.0001513756,0.002834348,0.03919272,0.00002861204,0.00007541855,0.0005372324,0.00009514506,0.000965206,0.9522496,0.0002886689,0.003572855,0.000008774619],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9868318,0.007459062,0.001548794,0.0001305281,0.00002759913,0.00003524651,0.0001140926,0.00003367473,0.003819223],"genre_scores_gemma":[0.993515,0.003972612,0.0009664542,0.00008933958,0.00002054618,0.00002241295,0.0001954179,0.000006439803,0.001211826],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001623016,"threshold_uncertainty_score":0.005429506,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01831710257843873,"score_gpt":0.2562510813835035,"score_spread":0.2379339788050648,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}