{"id":"W2058426499","doi":"10.1002/syn.10221","title":"Anesthetics inhibit high‐affinity states of dopamine D2 and other G‐linked receptors","year":2003,"lang":"en","type":"article","venue":"Synapse","topic":"Anesthesia and Sedative Agents","field":"Medicine","cited_by":69,"is_retracted":false,"has_abstract":true,"ca_institutions":"Centre for Addiction and Mental Health; University of Toronto","funders":"","keywords":"Chemistry; Receptor; Halothane; Pharmacology; Isoflurane; Dopamine; Stimulation; Dopamine receptor D2; Dopamine receptor; 5-HT receptor; D2-like receptor; Serotonin; Internal medicine; Biochemistry; Biology; Medicine; Dopamine receptor D1","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000195529,0.0001229207,0.0002721289,0.00006284138,0.0000328142,0.000004755636,0.00003621759,0.00007738019,0.0004582811],"category_scores_gemma":[0.0001256097,0.0000951293,0.00003751054,0.0001237169,0.0001679875,0.00003245196,0.00001116661,0.00009756708,0.00003177605],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001484101,"about_ca_system_score_gemma":0.00003377403,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00005921155,"about_ca_topic_score_gemma":0.000005557235,"domain_scores_codex":[0.9992384,0.00008363694,0.0002098824,0.0001675977,0.0001436811,0.0001568239],"domain_scores_gemma":[0.9994892,0.00006869838,0.0000833343,0.0001879342,0.00007015203,0.0001006514],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"not_applicable","study_design_scores_codex":[0.000466237,0.0009313659,0.9668106,0.0002981559,0.0001977618,0.0001710018,0.002777818,0.00001252834,0.01345155,0.00669341,0.002596262,0.005593333],"study_design_scores_gemma":[0.01149364,0.004453099,0.3033496,0.0004922379,0.000557762,0.0009127032,0.003853721,0.0001442785,0.2235065,0.003317618,0.4468432,0.00107557],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9982032,0.0001841263,0.00008173877,0.0002939698,0.00003856835,0.0001889776,0.000004099841,0.00002600727,0.0009793742],"genre_scores_gemma":[0.9964267,0.00008114077,0.0007664436,0.0004754613,0.0000187931,0.000004365389,0.00001676318,0.0000209875,0.002189356],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.663461,"threshold_uncertainty_score":0.5017856,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01831710257843873,"score_gpt":0.2562510813835035,"score_spread":0.2379339788050648,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}