{"id":"W2058450217","doi":"10.1016/s0006-8993(00)02525-7","title":"Receptor subtype and dose dependence of dexmedetomidine-induced accumulation of [14C]glutamine in astrocytes suggests glial involvement in its hypnotic-sedative and anesthetic-sparing effects","year":2000,"lang":"en","type":"article","venue":"Brain Research","topic":"Neuroscience and Neuropharmacology Research","field":"Neuroscience","cited_by":49,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Saskatchewan","funders":"","keywords":"Dexmedetomidine; Glutamatergic; Glutamate receptor; Agonist; Glutamine; Anesthetic; Pharmacology; Chemistry; In vivo; Neurotransmission; Alpha (finance); Sedative; Receptor; Anesthesia; Biology; Sedation; Medicine; Biochemistry; Amino acid; Surgery","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003676284,0.000525387,0.000979851,0.0002886532,0.0003851415,0.0004372662,0.0007184877,0.0005335949,0.004699855],"category_scores_gemma":[0.0008881764,0.0005564497,0.0007165645,0.0003268506,0.0005707216,0.0007609958,0.0002780015,0.0009512048,0.001492117],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005961654,"about_ca_system_score_gemma":0.0007051565,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002980588,"about_ca_topic_score_gemma":0.006582048,"domain_scores_codex":[0.9997165,0.00005603965,0.00003469002,0.00004783571,0.0000421943,0.0001028116],"domain_scores_gemma":[0.9992593,0.0002798443,0.00007763047,0.0002079229,0.00008330193,0.00009200288],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.005285272,0.0002811184,0.0005687115,0.0001360776,0.00004049183,0.0002047926,0.0001441943,0.0001545767,0.9889797,0.0005108465,0.0001474503,0.003546811],"study_design_scores_gemma":[0.0003089477,0.004989645,0.0340392,0.00003619818,0.0001700171,0.00155827,0.0002978892,0.001538137,0.9534697,0.0004057712,0.003154821,0.0000313952],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9827713,0.003110409,0.004903236,0.0003031707,0.00009260604,0.0002035077,0.001493647,0.00008350388,0.007038582],"genre_scores_gemma":[0.985459,0.00234354,0.00417257,0.00017196,0.00006808091,0.00023926,0.001597122,0.0000652907,0.005883192],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004699855,"threshold_uncertainty_score":0.01572257,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.172979900922362,"score_gpt":0.4315802883337152,"score_spread":0.2586003874113532,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}