{"id":"W2058450217","doi":"10.1016/s0006-8993(00)02525-7","title":"Receptor subtype and dose dependence of dexmedetomidine-induced accumulation of [14C]glutamine in astrocytes suggests glial involvement in its hypnotic-sedative and anesthetic-sparing effects","year":2000,"lang":"en","type":"article","venue":"Brain Research","topic":"Neuroscience and Neuropharmacology Research","field":"Neuroscience","cited_by":49,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Saskatchewan","funders":"","keywords":"Dexmedetomidine; Glutamatergic; Glutamate receptor; Agonist; Glutamine; Anesthetic; Pharmacology; Chemistry; In vivo; Neurotransmission; Alpha (finance); Sedative; Receptor; Anesthesia; Biology; Sedation; Medicine; Biochemistry; Amino acid; Surgery","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002091539,0.0001621781,0.0003133654,0.0007673305,0.0001180508,0.00004267351,0.0003988726,0.00009510195,0.00005691284],"category_scores_gemma":[0.003613345,0.0001540953,0.00002210792,0.001522356,0.0005704212,0.0003745789,0.0002814937,0.000584333,0.00000951212],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00006062797,"about_ca_system_score_gemma":0.0001750729,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001454098,"about_ca_topic_score_gemma":0.0001483747,"domain_scores_codex":[0.995882,0.001458603,0.000403633,0.0007045903,0.0008991077,0.000652026],"domain_scores_gemma":[0.995768,0.003662098,0.00008216833,0.0002215083,0.0001083384,0.000157934],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0007526312,0.0002224035,0.02600188,0.0001451779,0.000001267622,0.0001190804,0.0005362629,0.00007344581,0.9649009,0.0001300118,0.000009386647,0.007107541],"study_design_scores_gemma":[0.001139559,0.0008780466,0.1060161,0.0001098838,0.000001508066,0.00001398669,0.0000544813,0.003808343,0.8878095,0.0000559432,0.00001365927,0.00009901354],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9983408,0.00007718035,6.432534e-7,0.0004582903,0.00004188256,0.0009781066,0.000005150309,0.0000108784,0.00008701928],"genre_scores_gemma":[0.9992315,0.0004281935,0.0000238064,0.00007962765,0.00001912508,0.0000552445,6.858988e-7,0.00001682329,0.0001450652],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.08001421,"threshold_uncertainty_score":0.6283824,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.172979900922362,"score_gpt":0.4315802883337152,"score_spread":0.2586003874113532,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}