{"id":"W2058454627","doi":"10.1073/pnas.1115761109","title":"Deciphering the genetic architecture of variation in the immune response to <i>Mycobacterium tuberculosis</i> infection","year":2012,"lang":"en","type":"article","venue":"Proceedings of the National Academy of Sciences","topic":"Tuberculosis Research and Epidemiology","field":"Medicine","cited_by":277,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal","funders":"National Institute of Allergy and Infectious Diseases","keywords":"Expression quantitative trait loci; Biology; Mycobacterium tuberculosis; Genome-wide association study; Tuberculosis; Genetic architecture; Genetics; Quantitative trait locus; Genetic variation; Immune system; Population; Gene; Disease; Genotype; Virology; Single-nucleotide polymorphism; Medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005376263,0.0001952213,0.000213073,0.0006204353,0.0001440317,0.0003933822,0.0002364571,0.0003532991,0.0007028114],"category_scores_gemma":[0.001103622,0.000135752,0.000259309,0.00044826,0.0003559624,0.0001554542,0.0002805652,0.0004407928,0.00009458709],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001668075,"about_ca_system_score_gemma":0.0001235308,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002203438,"about_ca_topic_score_gemma":0.002310902,"domain_scores_codex":[0.9995682,0.0001465609,0.00002771452,0.0001488734,0.0000517202,0.00005697398],"domain_scores_gemma":[0.9994847,0.0002182708,0.0001582208,0.00006054692,0.00003920448,0.00003906586],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0006618546,0.00009882764,0.7648122,0.00006993375,0.0005470499,0.000411943,0.000364857,0.001402462,0.2104073,0.0007902854,0.0003109375,0.02012237],"study_design_scores_gemma":[0.000007682929,0.00006963242,0.9953234,0.000007256238,0.00008598841,0.0002273523,0.0001014598,0.001413321,0.002039322,0.0004186445,0.000298764,0.000007273413],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9985161,0.0002616787,0.0006836304,0.00008545656,0.000003885871,0.00000324357,0.0001402119,0.000009076443,0.0002965833],"genre_scores_gemma":[0.999135,0.0001250669,0.000430536,0.00007813021,0.000009265021,0.000003002269,0.0001183015,0.000005598161,0.0000951715],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002203438,"threshold_uncertainty_score":0.004381299,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03477710875740737,"score_gpt":0.335006963827704,"score_spread":0.3002298550702966,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}