{"id":"W2058472600","doi":"10.2174/1568009054629672","title":"Molecular Targets from VHL Studies into the Oxygen-Sensing Pathway","year":2005,"lang":"en","type":"review","venue":"Current Cancer Drug Targets","topic":"Cancer, Hypoxia, and Metabolism","field":"Biochemistry, Genetics and Molecular Biology","cited_by":20,"is_retracted":false,"has_abstract":true,"ca_institutions":"Canada Research Chairs; University of Toronto","funders":"National Cancer Institute; Terry Fox Foundation","keywords":"Ubiquitin ligase; Carcinogenesis; Hypoxia-inducible factors; Biology; Cancer research; Ubiquitin; Transcription factor; Vascular endothelial growth factor; Angiogenesis; Tumor suppressor gene; HIF1A; Cell biology; Cancer; Gene; Genetics; VEGF receptors","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003111864,0.0008204303,0.000928055,0.00151805,0.0002674165,0.0008397439,0.0007605405,0.0009387809,0.002793694],"category_scores_gemma":[0.0003158871,0.0002004491,0.0002368431,0.001358551,0.0004901171,0.001401346,0.0005617413,0.001471444,0.003491523],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007908228,"about_ca_system_score_gemma":0.0005690554,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005666475,"about_ca_topic_score_gemma":0.0008984451,"domain_scores_codex":[0.9999261,0.00001093279,0.000007471133,0.00001580722,0.00003096802,0.00000870711],"domain_scores_gemma":[0.9999082,0.00002699498,0.00001165502,0.000005140009,0.0000304243,0.00001762438],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0001267789,0.0001096895,0.0002114861,0.006474316,0.00004922411,0.0009582564,0.0000917847,0.0007580612,0.01320529,0.01080394,0.05018827,0.917023],"study_design_scores_gemma":[0.0000150674,0.00004559287,0.0002936842,0.0005191244,0.00002067189,0.001242589,0.00003034384,0.0000749451,0.001369012,0.002398826,0.9939813,0.000008800681],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.000314702,0.9953897,0.0003849652,0.000558792,0.0004872197,0.000005295392,0.00001388624,0.00001698859,0.002828442],"genre_scores_gemma":[0.001718578,0.9936904,0.0004150894,0.0004700223,0.0003215671,0.00000792039,0.00003265138,0.000002842959,0.003340969],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.002793694,"threshold_uncertainty_score":0.009345829,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03926531878117005,"score_gpt":0.3508890844591312,"score_spread":0.3116237656779611,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}