{"id":"W2058475260","doi":"10.1007/s00467-013-2724-0","title":"Conversion from twice- to once-daily tacrolimus in pediatric kidney recipients: a pharmacokinetic and bioequivalence study","year":2014,"lang":"en","type":"article","venue":"Pediatric Nephrology","topic":"Renal Transplantation Outcomes and Treatments","field":"Medicine","cited_by":18,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal; Centre Hospitalier Universitaire Sainte-Justine","funders":"Astellas Pharma","keywords":"Cmin; Bioequivalence; Pharmacokinetics; Tacrolimus; Medicine; Cmax; Pharmacology; Urology; Confidence interval; Internal medicine; Transplantation","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001235691,0.0001503546,0.0003640531,0.0001274821,0.0001204727,0.000318092,0.0001395402,0.0001806388,0.0006309939],"category_scores_gemma":[0.001944541,0.00005902673,0.0003105294,0.0002067642,0.0001823929,0.0001923283,0.0001037151,0.0003920037,0.0001218035],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002532553,"about_ca_system_score_gemma":0.0002624907,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000338961,"about_ca_topic_score_gemma":0.0002657163,"domain_scores_codex":[0.9993725,0.0002749086,0.00005187267,0.00008097511,0.000183897,0.00003579404],"domain_scores_gemma":[0.9989346,0.0003768485,0.0003897898,0.0001133804,0.00009665581,0.00008869993],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.04363592,0.005912199,0.6053137,0.0003556937,0.000975907,0.000815792,0.001487635,0.002132764,0.1299107,0.0003556489,0.0004873519,0.2086166],"study_design_scores_gemma":[0.001234148,0.06859857,0.8926148,0.00002372273,0.0005028388,0.002527688,0.000299428,0.002920614,0.02874961,0.00008057013,0.002420759,0.00002727138],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9995658,0.0001430084,0.0001614919,0.000005286744,0.00000169467,0.00001403926,0.00002172459,0.000002198467,0.00008467845],"genre_scores_gemma":[0.9993144,0.0001170422,0.0003665641,0.00001986283,0.000006072183,0.00001901079,0.00009551259,0.000002234377,0.00005920329],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001235691,"threshold_uncertainty_score":0.006535053,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01528782105828198,"score_gpt":0.2940340908240955,"score_spread":0.2787462697658135,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}