{"id":"W2058498380","doi":"10.3109/02656736.2012.736670","title":"Enhanced drug delivery in rabbit VX2 tumours using thermosensitive liposomes and MRI-controlled focused ultrasound hyperthermia","year":2012,"lang":"en","type":"article","venue":"International Journal of Hyperthermia","topic":"Ultrasound and Hyperthermia Applications","field":"Engineering","cited_by":75,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre; Ontario Institute for Cancer Research; University of Toronto; Sunnybrook Health Science Centre","funders":"Terry Fox Foundation; Fonds National de la Recherche Luxembourg; Natural Sciences and Engineering Research Council of Canada; Canada Research Chairs","keywords":"Doxorubicin; Hyperthermia; Liposome; Drug delivery; Medicine; Focused ultrasound; Magnetic resonance imaging; Drug; Cytotoxicity; Pharmacology; Ultrasound; Chemotherapy; Targeted drug delivery; Cancer research; Chemistry; Surgery; Radiology; In vitro; Internal medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0004463835,0.000300828,0.0005452867,0.0003659635,0.00006796195,0.00009358242,0.0003591011,0.0001112997,0.000109349],"category_scores_gemma":[0.00008863057,0.0002535017,0.0002037436,0.0001652186,0.00009195245,0.0006567881,0.00003103866,0.0003829779,0.00001924029],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002317022,"about_ca_system_score_gemma":0.00007307661,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00006364522,"about_ca_topic_score_gemma":0.00007486215,"domain_scores_codex":[0.9981967,0.00008423398,0.000695563,0.0001647585,0.0004384265,0.0004203736],"domain_scores_gemma":[0.9985823,0.0005488388,0.0002385801,0.0001581762,0.0002795137,0.0001925847],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000463234,0.0002505994,0.01467982,0.0000141226,0.0006496015,0.00005472035,0.003929158,0.003739443,0.9601441,0.0001797568,0.0001077411,0.01578771],"study_design_scores_gemma":[0.05856214,0.0003903414,0.3467897,0.001810609,0.001378057,0.009723195,0.009567464,0.02691117,0.5268069,0.003955395,0.009481947,0.004623094],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9929747,0.003652529,0.0007088284,0.0002196367,0.0007944225,0.000229595,0.000016579,0.00005068109,0.001353042],"genre_scores_gemma":[0.9968951,0.0008617584,0.001114217,0.0001950259,0.0007831302,0.00001264647,0.000004601348,0.00006933066,0.00006416488],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.4333372,"threshold_uncertainty_score":0.9999917,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008924603004527434,"score_gpt":0.2271083493622118,"score_spread":0.2181837463576844,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}