{"id":"W2058514583","doi":"10.1016/j.bmcl.2012.12.016","title":"Mitochondrial dysfunction contributes to the cytotoxicity of some 3,5-bis(benzylidene)-4-piperidone derivatives in colon HCT-116 cells","year":2012,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"Synthesis and biological activity","field":"Chemistry","cited_by":14,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Saskatchewan","funders":"Canadian Institutes of Health Research; Saskatchewan Health Research Foundation","keywords":"Chemistry; Cytotoxicity; Glutathione; Mitochondrion; Reactive oxygen species; Intracellular; Curcumin; Biochemistry; Thiol; Oxidative stress; In vitro; Enzyme","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.000403114,0.0003171585,0.0005192627,0.00003442977,0.0001023361,0.00002005808,0.0004335641,0.0002697413,0.001143103],"category_scores_gemma":[0.0008510632,0.0002115403,0.0001321082,0.0002894888,0.0002815596,0.0001253242,0.0001448509,0.0003966634,0.00002088353],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002643468,"about_ca_system_score_gemma":0.00005381455,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001268627,"about_ca_topic_score_gemma":0.000006970336,"domain_scores_codex":[0.9980499,0.00006818371,0.0005098207,0.000401513,0.0003868329,0.0005837376],"domain_scores_gemma":[0.9985045,0.0006025466,0.0002508073,0.0004036855,0.00005172611,0.0001867841],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003157675,0.0002530921,0.006557947,0.0001118625,0.0000598927,0.000004959624,0.0001966606,0.000002595165,0.9901131,0.000006829384,0.002027667,0.0003496662],"study_design_scores_gemma":[0.0007738325,0.00002456442,0.009464027,0.0001253388,0.0000494156,0.000007904651,0.0005307587,0.000006649594,0.985603,0.000008404394,0.003171522,0.0002346215],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.993511,0.000448271,0.0001829976,0.005020366,0.000362658,0.0001796263,0.00004836915,0.00004775502,0.0001990015],"genre_scores_gemma":[0.9967775,0.00003208588,0.00006816138,0.0012754,0.001669228,0.00004665301,0.00002192482,0.00002054787,0.00008853899],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0045101,"threshold_uncertainty_score":0.99977,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0135990544619866,"score_gpt":0.2184438856403705,"score_spread":0.2048448311783839,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}