{"id":"W2058514583","doi":"10.1016/j.bmcl.2012.12.016","title":"Mitochondrial dysfunction contributes to the cytotoxicity of some 3,5-bis(benzylidene)-4-piperidone derivatives in colon HCT-116 cells","year":2012,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"Synthesis and biological activity","field":"Chemistry","cited_by":14,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Saskatchewan","funders":"Canadian Institutes of Health Research; Saskatchewan Health Research Foundation","keywords":"Chemistry; Cytotoxicity; Glutathione; Mitochondrion; Reactive oxygen species; Intracellular; Curcumin; Biochemistry; Thiol; Oxidative stress; In vitro; Enzyme","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00008143238,0.0002171285,0.0001686897,0.0001194996,0.000130088,0.000112132,0.0001643817,0.0001843726,0.001209764],"category_scores_gemma":[0.0001104919,0.0001050943,0.0001453873,0.00009960571,0.0001194354,0.0001223887,0.00008633714,0.0004229169,0.0002261196],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001247173,"about_ca_system_score_gemma":0.0001526757,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008409952,"about_ca_topic_score_gemma":0.00101523,"domain_scores_codex":[0.9999574,0.00001010841,0.000005141713,0.00000603701,0.000009108513,0.00001220872],"domain_scores_gemma":[0.9999275,0.00001324875,0.00002072296,0.00001014974,0.00001231306,0.00001607164],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0006293749,0.00004119993,0.0003232717,0.00009183137,0.000006144848,0.0001581723,0.00002736494,0.0001808825,0.9960164,0.00008139596,0.00008241388,0.002361401],"study_design_scores_gemma":[0.00003592006,0.001049536,0.006100994,0.000009619818,0.00002822799,0.0003244972,0.00003030281,0.0009023614,0.9902047,0.00003879317,0.001269845,0.000005373776],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9963692,0.001642838,0.0006899307,0.00009714344,0.00002163934,0.000009527965,0.0001466405,0.00004233223,0.0009807787],"genre_scores_gemma":[0.9979347,0.0008267607,0.0003675289,0.00001438506,0.00000528902,0.000005132997,0.0001466575,0.000003088161,0.00069656],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001209764,"threshold_uncertainty_score":0.004047096,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0135990544619866,"score_gpt":0.2184438856403705,"score_spread":0.2048448311783839,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}