{"id":"W2058521801","doi":"10.1038/nature06968","title":"The ground state of embryonic stem cell self-renewal","year":2008,"lang":"en","type":"article","venue":"Nature","topic":"Pluripotent Stem Cells Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":3535,"is_retracted":false,"has_abstract":false,"ca_institutions":"Lunenfeld-Tanenbaum Research Institute; Mount Sinai Hospital; McMaster University","funders":"Biotechnology and Biological Sciences Research Council; Canadian Institutes of Health Research","keywords":"Embryonic stem cell; Cell biology; Induced pluripotent stem cell; Biology; Stem cell; Kinase; Cellular differentiation; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005297101,0.0001414555,0.0002779817,0.0003297677,0.0004674827,0.002852087,0.0005053352,0.0008646293,0.003128008],"category_scores_gemma":[0.001125251,0.0002152848,0.0001527408,0.0003260333,0.001581275,0.003160178,0.0008068994,0.00154022,0.0009485721],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007836713,"about_ca_system_score_gemma":0.000597392,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003022723,"about_ca_topic_score_gemma":0.0002720029,"domain_scores_codex":[0.9997894,0.00002048835,0.00001505459,0.00004553587,0.00008598017,0.00004362594],"domain_scores_gemma":[0.9995789,0.0001582044,0.00004612887,0.00009639054,0.00006155167,0.00005875188],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"theoretical_or_conceptual","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002766565,0.00006720638,0.001910527,0.0002493586,0.00003139134,0.0002244247,0.0005176013,0.001265791,0.3314369,0.5747952,0.005303159,0.08392179],"study_design_scores_gemma":[0.0000667297,0.000448192,0.01021771,0.0001383419,0.00004956964,0.0006714813,0.0006817818,0.005884424,0.28921,0.5816585,0.1109163,0.00005703085],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.78067,0.03485392,0.08242687,0.01909888,0.001659661,0.00005584215,0.001444547,0.0008516085,0.07893866],"genre_scores_gemma":[0.9848722,0.004754162,0.003134819,0.000503325,0.0002815916,0.00002523202,0.0004561663,0.00005416742,0.005918341],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003128008,"threshold_uncertainty_score":0.01046425,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006992035737366256,"score_gpt":0.2410478230602973,"score_spread":0.2340557873229311,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}