{"id":"W2058553784","doi":"10.1038/nature09591","title":"Direct conversion of human fibroblasts to multilineage blood progenitors","year":2010,"lang":"en","type":"article","venue":"Nature","topic":"Pluripotent Stem Cells Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":690,"is_retracted":false,"has_abstract":false,"ca_institutions":"McMaster University","funders":"Canadian Institutes of Health Research","keywords":"Reprogramming; Haematopoiesis; Embryonic stem cell; Biology; Cell biology; Induced pluripotent stem cell; Stem cell; Progenitor cell; Embryoid body; Cellular differentiation; Immunology; Cell; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002951836,0.000317782,0.0001884448,0.0003129761,0.0001754675,0.0004362296,0.0002598461,0.0002544925,0.002135523],"category_scores_gemma":[0.0002240375,0.0001855023,0.0003516588,0.0001603628,0.0001393419,0.0001308541,0.0003154333,0.0006560507,0.001014097],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001466202,"about_ca_system_score_gemma":0.0001996429,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005853036,"about_ca_topic_score_gemma":0.001028049,"domain_scores_codex":[0.9998125,0.00002689034,0.00002320897,0.00004078207,0.00006143017,0.00003516942],"domain_scores_gemma":[0.9998503,0.00005805687,0.00001093576,0.00003947714,0.00001491325,0.0000263475],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0000923027,0.00002715701,0.0001641452,0.00003180986,0.000008661626,0.000124847,0.00006000474,0.00008526906,0.9950177,0.0005140144,0.0001013352,0.003772742],"study_design_scores_gemma":[0.0000142738,0.00006687223,0.0009043986,0.000003619991,0.00001232715,0.0001963099,0.00001557776,0.0001928669,0.9938207,0.0001012404,0.004669732,0.000002137368],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9459572,0.00253193,0.02754707,0.0002304368,0.0003055195,0.0003134482,0.002462714,0.000315482,0.02033616],"genre_scores_gemma":[0.9697212,0.001332686,0.008449049,0.00009781098,0.00003205433,0.00009183209,0.002036598,0.00007920106,0.01815971],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002135523,"threshold_uncertainty_score":0.007144034,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.005194584906254189,"score_gpt":0.2783124998269453,"score_spread":0.2731179149206911,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}