{"id":"W2058553784","doi":"10.1038/nature09591","title":"Direct conversion of human fibroblasts to multilineage blood progenitors","year":2010,"lang":"en","type":"article","venue":"Nature","topic":"Pluripotent Stem Cells Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":690,"is_retracted":false,"has_abstract":false,"ca_institutions":"McMaster University","funders":"Canadian Institutes of Health Research","keywords":"Reprogramming; Haematopoiesis; Embryonic stem cell; Biology; Cell biology; Induced pluripotent stem cell; Stem cell; Progenitor cell; Embryoid body; Cellular differentiation; Immunology; Cell; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001270714,0.00009707581,0.0001018552,0.00005313638,0.00004611403,0.000007682029,0.0002435095,0.0008267929,0.00004010202],"category_scores_gemma":[0.0001172661,0.00008587066,0.00007096257,0.0000960718,0.00004449192,0.00000181191,0.0001572569,0.0006590802,0.00001441993],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000002895078,"about_ca_system_score_gemma":0.00003211105,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000009087652,"about_ca_topic_score_gemma":0.00002973579,"domain_scores_codex":[0.9992292,0.00002678749,0.0001084466,0.0002610058,0.0001943893,0.0001801593],"domain_scores_gemma":[0.9993961,0.000009041449,0.00003728512,0.0003210105,0.0001324097,0.0001041334],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00004174405,0.00007525041,0.003222782,0.0000435801,0.00002661875,0.000004197258,0.00001609333,0.000002321669,0.9936061,0.000005088694,0.00283111,0.0001251184],"study_design_scores_gemma":[0.0003688956,0.0002347188,0.002598586,0.000009990404,0.000008622153,0.000004422739,0.000007253835,0.000007507547,0.9715229,0.000001025963,0.02514644,0.00008969472],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9977939,0.0001482027,0.000003419068,0.0000707151,0.0001838849,0.0002330597,0.00002844191,0.00001009266,0.001528355],"genre_scores_gemma":[0.9972811,0.000007290812,0.0005350803,0.00007209936,0.0002065029,0.00000718488,0.00007130203,0.00001582611,0.001803583],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02231533,"threshold_uncertainty_score":0.6376984,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.005194584906254189,"score_gpt":0.2783124998269453,"score_spread":0.2731179149206911,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}