{"id":"W2058566085","doi":"10.1021/jm800175e","title":"Selective Nucleoside Triphosphate Diphosphohydrolase-2 (NTPDase2) Inhibitors: Nucleotide Mimetics Derived from Uridine-5′-carboxamide","year":2008,"lang":"en","type":"article","venue":"Journal of Medicinal Chemistry","topic":"Adenosine and Purinergic Signaling","field":"Biochemistry, Genetics and Molecular Biology","cited_by":53,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université Laval; Centre hospitalier universitaire de Québec","funders":"Canadian Institutes of Health Research; Deutscher Akademischer Austauschdienst","keywords":"Chemistry; Nucleoside; Uridine; Nucleotide; Uracil; Stereochemistry; Nucleoside triphosphate; Carboxamide; Ribonucleoside; Amide; Uridine triphosphate; Biochemistry; RNA; DNA","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001104376,0.0004323736,0.0003123566,0.000146427,0.00009178289,0.0001970196,0.000222032,0.0002204604,0.0008751879],"category_scores_gemma":[0.00009108076,0.000118713,0.0001232006,0.0001539524,0.0001048686,0.0001901283,0.0001579324,0.0003850154,0.0002964163],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002321906,"about_ca_system_score_gemma":0.0001532327,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002233129,"about_ca_topic_score_gemma":0.00062635,"domain_scores_codex":[0.9999313,0.00001376327,0.000007005202,0.00001777741,0.00001508766,0.00001496634],"domain_scores_gemma":[0.9999729,0.000005575341,0.000008051662,0.00000185035,0.000002867163,0.000008672049],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002789315,0.00009600002,0.0001543152,0.0001243084,0.00001160859,0.000160823,0.00002210805,0.0004053415,0.988189,0.0003795816,0.0001113643,0.01006649],"study_design_scores_gemma":[0.000129216,0.001139167,0.0007215517,0.000007419156,0.00002192351,0.0004393301,0.000008040755,0.0006909571,0.9890645,0.00005612252,0.007715648,0.000006154299],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9636732,0.01664794,0.01222623,0.0001332799,0.00009581124,0.0002584209,0.0005644304,0.000117616,0.006283021],"genre_scores_gemma":[0.9758334,0.007999912,0.01172777,0.00008760803,0.00003690066,0.0001585383,0.0006655026,0.00001777097,0.003472608],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0008751879,"threshold_uncertainty_score":0.00292778,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008710896690788842,"score_gpt":0.2193458103346828,"score_spread":0.2106349136438939,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}