{"id":"W2058590353","doi":"10.1074/jbc.m110.197053","title":"Structural Basis of Rnd1 Binding to Plexin Rho GTPase Binding Domains (RBDs)","year":2011,"lang":"en","type":"article","venue":"Journal of Biological Chemistry","topic":"Axon Guidance and Neuronal Signaling","field":"Neuroscience","cited_by":47,"is_retracted":false,"has_abstract":true,"ca_institutions":"Structural Genomics Consortium; University of Toronto","funders":"Argonne National Laboratory; National Institute of General Medical Sciences; National Heart, Lung, and Blood Institute; Canadian Institutes of Health Research","keywords":"GTPase; Allosteric regulation; Plexin; Chemistry; Semaphorin; Receptor; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000328531,0.0001882619,0.0003798383,0.00007318306,0.0001130602,0.00001847122,0.0005541876,0.0001485065,0.0007671637],"category_scores_gemma":[0.001120571,0.0001281583,0.0002297503,0.0003192005,0.0001564675,0.0001229866,0.0001394908,0.0003897136,0.00001609843],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00005668213,"about_ca_system_score_gemma":0.00004603498,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000002767603,"about_ca_topic_score_gemma":1.351627e-7,"domain_scores_codex":[0.9983034,0.00007184947,0.0006716894,0.0002768009,0.0003307423,0.0003455438],"domain_scores_gemma":[0.9986786,0.0002654128,0.0005702798,0.0001530349,0.00007165276,0.0002610316],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002467634,0.00004577304,0.004553611,0.00002067069,0.000008445701,0.0001532034,0.0001031348,0.00001027265,0.9942636,0.00004718561,0.00006788424,0.0004794079],"study_design_scores_gemma":[0.0003298655,0.0002813419,0.00183993,0.00008057935,0.000012042,0.0002559854,0.0001249214,0.00001348769,0.9965002,0.0002365436,0.0001684672,0.0001566217],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9982139,0.00004098663,0.00006823548,0.00008719876,0.0001485668,0.00005877376,0.00002590442,0.00001709873,0.001339292],"genre_scores_gemma":[0.9985182,0.00004447406,0.0008720354,0.0002736306,0.0002055371,0.000001487116,7.652244e-7,0.00001091329,0.00007290101],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002713681,"threshold_uncertainty_score":0.8399905,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1228826799466603,"score_gpt":0.2960032477531943,"score_spread":0.173120567806534,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}