{"id":"W2058595915","doi":"10.1097/00001813-200112004-00003","title":"Maximizing the response to Herceptin® therapy through optimal use and patient selection","year":2001,"lang":"en","type":"review","venue":"Anti-Cancer Drugs","topic":"HER2/EGFR in Cancer Research","field":"Medicine","cited_by":21,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University","funders":"","keywords":"Immunohistochemistry; Medicine; Concordance; Oncology; Breast cancer; Trastuzumab; Metastatic breast cancer; Internal medicine; Targeted therapy; Cancer; Disease; Fluorescence in situ hybridization; Gene; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0008420337,0.0005864025,0.001482267,0.0002377915,0.0003068845,0.0002139531,0.0003067367,0.0003411278,0.0006119823],"category_scores_gemma":[0.0001875573,0.0003741118,0.0003569628,0.001295144,0.0001826151,0.0001978004,0.0001934881,0.001120393,0.0001281742],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007511907,"about_ca_system_score_gemma":0.001054216,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001329531,"about_ca_topic_score_gemma":0.00002602349,"domain_scores_codex":[0.9960467,0.0007814813,0.0006679043,0.0008838049,0.0008394052,0.0007807594],"domain_scores_gemma":[0.9978834,0.0005897749,0.000242819,0.0007723544,0.0002689068,0.0002427188],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0006645375,0.00008119849,0.0001446259,0.001429354,0.0002608382,0.00002993592,0.002177771,0.000008980207,0.00005548852,0.000005423769,0.01197786,0.983164],"study_design_scores_gemma":[0.0006280463,0.0005447843,0.0001783065,0.007664186,0.0002315172,0.0001438874,0.0002749382,0.00001091897,0.00009158802,0.000002358993,0.9898449,0.0003845227],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.01882774,0.9748539,0.00004529744,0.002119873,0.0003444452,0.003248486,0.00005468568,0.0001035331,0.0004020002],"genre_scores_gemma":[0.000341002,0.9930012,0.0008608064,0.001901197,0.0005516855,0.0008809076,0.00001867359,0.0001813067,0.002263178],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9827794,"threshold_uncertainty_score":0.9998711,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1727720393999385,"score_gpt":0.4460614837562243,"score_spread":0.2732894443562859,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}