{"id":"W205863296","doi":"10.1096/fasebj.20.5.lb101-a","title":"The hypocholesterolemic effects of guar gum consumption are mediated by increased nuclear form of sterol regulatory element binding protein 2 (SREBP2) in the pig model","year":2006,"lang":"en","type":"article","venue":"The FASEB Journal","topic":"Cholesterol and Lipid Metabolism","field":"Medicine","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"Agriculture and Agri-Food Canada; University of Guelph","funders":"","keywords":"LDL receptor; Guar gum; Sterol regulatory element-binding protein; Cholesterol; Endocrinology; Internal medicine; Chemistry; Sterol; Reductase; Messenger RNA; PCSK9; Lipoprotein; Biochemistry; Biology; Enzyme; Gene; Medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000512036,0.0006425771,0.0006256638,0.000633811,0.0002742804,0.0003179132,0.0003819398,0.0006857757,0.001551396],"category_scores_gemma":[0.0001800483,0.0004556403,0.0006725611,0.0001985508,0.0008615338,0.0004467847,0.0002792112,0.001292731,0.0003327419],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003424784,"about_ca_system_score_gemma":0.000272775,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006206888,"about_ca_topic_score_gemma":0.0008099974,"domain_scores_codex":[0.9997458,0.00006237922,0.00001981962,0.00005825183,0.00004360473,0.00007018442],"domain_scores_gemma":[0.9997649,0.00003551354,0.0000601373,0.00004361654,0.00001992425,0.00007596979],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.003908667,0.0006236071,0.0006926358,0.000046765,0.00001684833,0.0001269005,0.00003666911,0.00003585532,0.9934182,0.00003965251,0.00002766631,0.00102647],"study_design_scores_gemma":[0.000669555,0.04469133,0.05401566,0.00003132832,0.0002718729,0.0009368955,0.0002864904,0.001829878,0.8949599,0.000194071,0.002070441,0.00004249313],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9983662,0.0002717666,0.0009124699,0.00007992284,0.00003313043,0.00003286937,0.00007738722,0.00002394671,0.0002024696],"genre_scores_gemma":[0.9926209,0.0008117857,0.00252979,0.0001891476,0.00003291613,0.0002090582,0.0003856471,0.00002711558,0.003193654],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001551396,"threshold_uncertainty_score":0.005189896,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009119268403799452,"score_gpt":0.2230920168098663,"score_spread":0.2139727484060669,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}