{"id":"W2058694635","doi":"10.1074/jbc.m112.415117","title":"Choline Supplementation Promotes Hepatic Insulin Resistance in Phosphatidylethanolamine N-Methyltransferase-deficient Mice via Increased Glucagon Action","year":2012,"lang":"en","type":"article","venue":"Journal of Biological Chemistry","topic":"Neurological and metabolic disorders","field":"Medicine","cited_by":35,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"Canadian Institutes of Health Research; Alberta Innovates; University of Alberta; Genome Canada","keywords":"Internal medicine; Endocrinology; Glucagon; IRS1; Insulin; Insulin resistance; Glucose homeostasis; Biology; Insulin receptor; Chemistry; Medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006619287,0.0001789044,0.000438956,0.00005499839,0.00003203927,0.000008301823,0.0001041267,0.0001777083,0.0004214071],"category_scores_gemma":[0.0005855419,0.0001169454,0.0001405761,0.0002805975,0.00008178645,0.0001079851,0.00001867786,0.0004547714,0.000005367277],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00007110049,"about_ca_system_score_gemma":0.00004189515,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001785278,"about_ca_topic_score_gemma":0.000003745327,"domain_scores_codex":[0.9984565,0.00009686556,0.000670659,0.0001727006,0.0002749668,0.0003282991],"domain_scores_gemma":[0.9991333,0.0001465913,0.0002781934,0.000109426,0.0001106527,0.0002218078],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001516548,0.001382969,0.03969739,0.0001373026,0.00002571096,0.00002759793,0.00008578794,0.000001386923,0.9528763,0.000005491864,0.00004499597,0.00419854],"study_design_scores_gemma":[0.003192563,0.0003988765,0.1505048,0.00008102605,0.00006476601,0.0001042889,0.0001028684,0.00001540566,0.8418671,0.0001324082,0.003402343,0.0001335664],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9950423,0.00290999,0.0002883198,0.0009700371,0.0001072153,0.0002048491,0.000009541085,0.00001816839,0.0004496319],"genre_scores_gemma":[0.9967842,0.0009924102,0.001234518,0.0005593867,0.0002923364,0.00001138075,0.00004816667,0.000009346202,0.00006830035],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1110092,"threshold_uncertainty_score":0.4768894,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02637497508266836,"score_gpt":0.2890210243438599,"score_spread":0.2626460492611916,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}