{"id":"W2058698228","doi":"10.4161/pri.25566","title":"Implications of prion polymorphisms","year":2013,"lang":"en","type":"review","venue":"Prion","topic":"Prion Diseases and Protein Misfolding","field":"Biochemistry, Genetics and Molecular Biology","cited_by":11,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"","keywords":"PRNP; Chronic wasting disease; Biology; Phenotype; Incubation period; Genetics; Prion protein; Incubation; In vitro; Gene; Disease; Host adaptation; In vivo; Strain (injury); Genotype; Scrapie; Biochemistry; Genome; Pathology; Medicine; Anatomy","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00009418995,0.0002073682,0.0004395004,0.00006374434,0.00004529852,0.00001587755,0.0002900691,0.0002846489,0.0001010304],"category_scores_gemma":[0.00005273363,0.0001765254,0.0003678401,0.0001015378,0.00003612204,0.000002468961,0.0001717167,0.00008877157,0.00005912353],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001930612,"about_ca_system_score_gemma":0.000172576,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0000120156,"about_ca_topic_score_gemma":0.00000101593,"domain_scores_codex":[0.9990069,0.00006876303,0.0003619593,0.0003157679,0.0000828608,0.0001637468],"domain_scores_gemma":[0.9989613,0.00001192186,0.0003324351,0.0005519202,0.00006036495,0.00008201043],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.000001961445,0.00002419191,0.000005886826,0.001352193,0.00004816902,8.963993e-8,0.000002141894,1.699023e-7,0.002194796,0.0001359494,0.00138062,0.9948539],"study_design_scores_gemma":[0.00006280271,0.00005065715,0.00002384116,0.0009046941,0.0001514517,0.000009125845,9.800025e-7,5.360841e-7,0.0007127815,0.0001019473,0.9977967,0.0001845263],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.00006423617,0.99822,0.0004335068,0.00002510339,0.0000821671,0.0006754276,0.00005620599,0.00001100264,0.0004323878],"genre_scores_gemma":[0.0001686189,0.9981523,0.0005027881,0.00002581917,0.0001807064,0.0001804612,0.0005643773,0.00003559532,0.0001893666],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.996416,"threshold_uncertainty_score":0.7198496,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04030432512879015,"score_gpt":0.3341265638510021,"score_spread":0.293822238722212,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}