{"id":"W2058710346","doi":"10.1038/ncomms7217","title":"CEACAM1 induces B-cell survival and is essential for protective antiviral antibody production","year":2015,"lang":"en","type":"article","venue":"Nature Communications","topic":"Immunotherapy and Immune Responses","field":"Immunology and Microbiology","cited_by":74,"is_retracted":false,"has_abstract":true,"ca_institutions":"Occupational Cancer Research Centre","funders":"Canadian Institutes of Health Research; Mercator Research Center Ruhr; Deutsche Forschungsgemeinschaft; Alexander von Humboldt-Stiftung; Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung; Stem Cell Network; National Science Foundation","keywords":"Vesicular stomatitis virus; Antibody; B cell; Biology; Immune system; Neutralizing antibody; Bruton's tyrosine kinase; Virology; Syk; Immunology; Cancer research; Virus; Cell biology; Signal transduction; Tyrosine kinase","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005112006,0.0001604351,0.0002124307,0.0001177604,0.0005050566,0.00003892539,0.0004952062,0.0004696228,0.00001077309],"category_scores_gemma":[0.000323182,0.0001452436,0.00006846688,0.0001870064,0.0003959904,0.0002144088,0.0001919967,0.0008164253,0.00003794673],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003019562,"about_ca_system_score_gemma":0.0001301835,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00005314126,"about_ca_topic_score_gemma":0.00002741971,"domain_scores_codex":[0.9988452,0.0004394028,0.0002061054,0.0002507248,0.00004009179,0.0002184466],"domain_scores_gemma":[0.9984496,0.0002206108,0.0001358515,0.0008808538,0.0002975978,0.00001544676],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000668331,0.0003589565,0.0004925407,0.00001526466,0.0001573939,1.401543e-7,0.002103467,2.253821e-7,0.9840853,0.002126546,0.006152761,0.003839032],"study_design_scores_gemma":[0.002443312,0.000353953,0.004591085,0.00003489963,0.00007795625,0.00002945177,0.001878272,0.000007867501,0.6691687,0.0006501916,0.3204444,0.0003199471],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.924337,0.06281116,0.0003611032,0.007163376,0.001714691,0.001441187,0.00009332091,0.0001293374,0.001948857],"genre_scores_gemma":[0.9960627,0.0007510229,0.0006624686,0.0001119048,0.0000491723,0.0001157589,0.0002679467,0.00002090322,0.001958105],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.3149167,"threshold_uncertainty_score":0.5922862,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02745679422143523,"score_gpt":0.3235083514922616,"score_spread":0.2960515572708264,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}