{"id":"W2058710346","doi":"10.1038/ncomms7217","title":"CEACAM1 induces B-cell survival and is essential for protective antiviral antibody production","year":2015,"lang":"en","type":"article","venue":"Nature Communications","topic":"Immunotherapy and Immune Responses","field":"Immunology and Microbiology","cited_by":74,"is_retracted":false,"has_abstract":true,"ca_institutions":"Occupational Cancer Research Centre","funders":"Canadian Institutes of Health Research; Mercator Research Center Ruhr; Deutsche Forschungsgemeinschaft; Alexander von Humboldt-Stiftung; Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung; Stem Cell Network; National Science Foundation","keywords":"Vesicular stomatitis virus; Antibody; B cell; Biology; Immune system; Neutralizing antibody; Bruton's tyrosine kinase; Virology; Syk; Immunology; Cancer research; Virus; Cell biology; Signal transduction; Tyrosine kinase","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0000776608,0.0002349203,0.0002302135,0.0001996038,0.0001437851,0.000336767,0.0001164647,0.0002657345,0.001661815],"category_scores_gemma":[0.0001117542,0.0001128739,0.0002044478,0.0001015673,0.0001601584,0.0001637012,0.0002330854,0.0006580305,0.0005002605],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002945671,"about_ca_system_score_gemma":0.0001570198,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005214193,"about_ca_topic_score_gemma":0.0006617495,"domain_scores_codex":[0.9998717,0.00001539322,0.000007340861,0.00002263863,0.0000359849,0.00004679033],"domain_scores_gemma":[0.9998822,0.00001918648,0.00002680309,0.0000158223,0.0000145252,0.00004136004],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00003342521,0.000007260269,0.0001191054,0.00001888039,0.000001840639,0.00002164853,0.000003659072,0.00001858925,0.9988697,0.00005727356,0.00003167942,0.0008168922],"study_design_scores_gemma":[0.000009251424,0.0001757955,0.007067944,0.000006063513,0.00000894349,0.0002174421,0.00001356401,0.0004285273,0.9887056,0.00006381705,0.003300297,0.000002848855],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9907606,0.00391776,0.001482431,0.0001398583,0.00003733836,0.00001432046,0.0004618909,0.0001313088,0.003054678],"genre_scores_gemma":[0.9960068,0.0006266151,0.0007616075,0.00004687604,0.00001606783,0.00001318509,0.0004768712,0.00002038591,0.002031636],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001661815,"threshold_uncertainty_score":0.005559325,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02745679422143523,"score_gpt":0.3235083514922616,"score_spread":0.2960515572708264,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}