{"id":"W2058751269","doi":"10.1074/jbc.m114.584805","title":"A Pivotal Role for Pro-335 in Balancing the Dual Functions of Munc18-1 Domain-3a in Regulated Exocytosis","year":2014,"lang":"en","type":"article","venue":"Journal of Biological Chemistry","topic":"Cellular transport and secretion","field":"Biochemistry, Genetics and Molecular Biology","cited_by":39,"is_retracted":false,"has_abstract":true,"ca_institutions":"Toronto Rehabilitation Institute; University of Toronto; University Health Network","funders":"Canadian Institutes of Health Research; Heart and Stroke Foundation of Canada","keywords":"Exocytosis; Syntaxin; Cell biology; Munc-18; Syntaxin 3; Mutant; Biology; Chemistry; Secretion; Biochemistry; Vesicle; Gene; Synaptic vesicle; Membrane","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002035296,0.0003834983,0.0002388455,0.000120459,0.0002939588,0.0004258781,0.0002921693,0.000525971,0.001199375],"category_scores_gemma":[0.0001435392,0.0001239874,0.0004337609,0.00008958139,0.0003602099,0.000414798,0.0004530471,0.000530016,0.0007042201],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002673857,"about_ca_system_score_gemma":0.000254247,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00027423,"about_ca_topic_score_gemma":0.0002496023,"domain_scores_codex":[0.9998749,0.00002521241,0.00001521593,0.00002738076,0.00003307236,0.00002418894],"domain_scores_gemma":[0.9998754,0.0000152059,0.00003714355,0.00001584865,0.00001534578,0.00004088331],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001075081,0.00001012397,0.0003402417,0.00002211227,0.000004348082,0.0001448542,0.00001424507,0.0001150706,0.998181,0.000320609,0.00001630208,0.0007236428],"study_design_scores_gemma":[0.00003537587,0.0001793498,0.007312274,0.00001471179,0.00002260437,0.001440493,0.00006030259,0.002775802,0.985253,0.0003730406,0.002514788,0.00001827946],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9939741,0.0005156703,0.004345499,0.0001334857,0.00002157049,0.0000188343,0.0001251858,0.0000791247,0.0007864965],"genre_scores_gemma":[0.9969158,0.0001308985,0.002181384,0.00005121571,0.000004156818,0.00001090956,0.0001202741,0.00001708351,0.0005683384],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001199375,"threshold_uncertainty_score":0.004012287,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01067849899926664,"score_gpt":0.215702892357823,"score_spread":0.2050243933585564,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}