{"id":"W2058751269","doi":"10.1074/jbc.m114.584805","title":"A Pivotal Role for Pro-335 in Balancing the Dual Functions of Munc18-1 Domain-3a in Regulated Exocytosis","year":2014,"lang":"en","type":"article","venue":"Journal of Biological Chemistry","topic":"Cellular transport and secretion","field":"Biochemistry, Genetics and Molecular Biology","cited_by":39,"is_retracted":false,"has_abstract":true,"ca_institutions":"Toronto Rehabilitation Institute; University of Toronto; University Health Network","funders":"Canadian Institutes of Health Research; Heart and Stroke Foundation of Canada","keywords":"Exocytosis; Syntaxin; Cell biology; Munc-18; Syntaxin 3; Mutant; Biology; Chemistry; Secretion; Biochemistry; Vesicle; Gene; Synaptic vesicle; Membrane","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005881384,0.0001049009,0.0002205645,0.00002471785,0.00002983677,0.000006394982,0.0001352022,0.0002367998,0.0000196681],"category_scores_gemma":[0.0001470509,0.00006714695,0.0001689874,0.00009998294,0.0000761784,0.000003406268,0.00002477738,0.0001778874,2.387324e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002040215,"about_ca_system_score_gemma":0.00004242275,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000005680291,"about_ca_topic_score_gemma":0.00001826034,"domain_scores_codex":[0.999104,0.000043496,0.0004493464,0.0001454374,0.00009233227,0.0001654253],"domain_scores_gemma":[0.999483,0.00004069436,0.0002190004,0.000129132,0.00008436373,0.00004379688],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004062904,0.00009967875,0.02774336,0.00002411415,0.00001971017,0.000002556917,0.00003764498,0.00009228358,0.9712703,0.000008320751,0.00002145472,0.0002742363],"study_design_scores_gemma":[0.002051837,0.0006255114,0.04771522,0.00007790528,0.0000233656,0.0000920076,0.0004997795,0.0002169721,0.9395273,0.0005197286,0.008475499,0.000174917],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9969276,0.0004148963,0.002155751,0.0001137646,0.00004405442,0.00010041,0.000009395592,0.000002166462,0.0002319484],"genre_scores_gemma":[0.99923,0.00005399642,0.0002479004,0.00003035764,0.0002072723,0.000008743023,0.0001636771,0.000006260809,0.00005183261],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.03174309,"threshold_uncertainty_score":0.2738173,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01067849899926664,"score_gpt":0.215702892357823,"score_spread":0.2050243933585564,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}