{"id":"W2058778390","doi":"10.1016/j.bbrc.2009.08.166","title":"A model for the generation of localized transient [Na+] elevations in vascular smooth muscle","year":2009,"lang":"en","type":"article","venue":"Biochemical and Biophysical Research Communications","topic":"Ion Channels and Receptors","field":"Neuroscience","cited_by":21,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Northern British Columbia; University of British Columbia","funders":"Canada Foundation for Innovation; Canadian Institutes of Health Research; Western Canada Research Grid","keywords":"SERCA; Endoplasmic reticulum; TRPC6; Biophysics; Chemistry; Cytoplasm; Ion transporter; Transient receptor potential channel; ATPase; Biochemistry; Biology; Receptor; Membrane","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003972339,0.00006937155,0.0001102213,0.00007063067,0.0003176666,0.00002786835,0.0004973235,0.00006103513,0.000003133504],"category_scores_gemma":[0.000537929,0.00004520912,0.00007914988,0.0005077363,0.0005412271,0.00005135978,0.000078124,0.0002363404,0.000001494029],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002393306,"about_ca_system_score_gemma":0.00005359958,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002639955,"about_ca_topic_score_gemma":0.000007224938,"domain_scores_codex":[0.9989503,0.000146737,0.0002014814,0.0002000871,0.0002919808,0.0002094049],"domain_scores_gemma":[0.9986187,0.0007155122,0.00002731685,0.0004395495,0.0001327479,0.00006616062],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"simulation_or_modeling","study_design_scores_codex":[0.00001424883,0.0003709144,3.623824e-7,0.000006525607,0.000001462036,2.995514e-8,0.000235475,0.0001119781,0.9734515,0.01839436,0.0003096157,0.00710353],"study_design_scores_gemma":[0.0002915208,0.00006784376,0.0001344367,0.00001384174,0.000004816215,8.438587e-8,0.00004254732,0.7016047,0.2935561,0.003132284,0.001096224,0.00005567529],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9655001,0.0004941672,0.01517345,0.01766232,0.00002321977,0.0009317139,0.00005232116,0.0000208606,0.000141879],"genre_scores_gemma":[0.9977025,0.0009651672,0.0009778187,0.0001442723,0.000037231,0.0001164839,0.00001542673,0.000004978953,0.00003605443],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.7014927,"threshold_uncertainty_score":0.2443267,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.2443810766909848,"score_gpt":0.3954111858820216,"score_spread":0.1510301091910368,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}