{"id":"W2058806672","doi":"10.1038/onc.2012.19","title":"Coordinate regulation of estrogen receptor β degradation by Mdm2 and CREB-binding protein in response to growth signals","year":2012,"lang":"en","type":"article","venue":"Oncogene","topic":"Estrogen and related hormone effects","field":"Biochemistry, Genetics and Molecular Biology","cited_by":37,"is_retracted":false,"has_abstract":false,"ca_institutions":"Université de Montréal","funders":"Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research; Cancer Research Society","keywords":"Biology; Protein kinase B; Estrogen receptor; Ubiquitin ligase; Phosphorylation; Cancer research; Estrogen receptor alpha; Signal transduction; Cell biology; Ubiquitin; Breast cancer; Cancer; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005628941,0.0001114351,0.000126398,0.00007792106,0.00003555733,0.000007895927,0.00006108064,0.0001644129,0.000009395947],"category_scores_gemma":[0.000140548,0.0001073504,0.00003195359,0.0001523997,0.00002865571,0.00001007312,0.00004783589,0.00005630118,0.000008748321],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002620529,"about_ca_system_score_gemma":0.00002959157,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001724259,"about_ca_topic_score_gemma":0.000001037156,"domain_scores_codex":[0.999142,0.0001810284,0.0001885785,0.000183908,0.00009637324,0.0002081204],"domain_scores_gemma":[0.9996182,0.00001870897,0.00008521417,0.0001244913,0.00004370254,0.0001096865],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0007032509,0.00005908306,0.003929727,0.00001334193,0.00002127405,3.499376e-7,0.00005462309,0.000005095856,0.9929135,0.00003595091,0.0006267419,0.001637047],"study_design_scores_gemma":[0.0004994083,0.0003694798,0.001064985,0.0000350306,0.00001056138,0.000004989512,0.00002766368,0.00001109095,0.9955859,0.000009816151,0.002258042,0.0001230501],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9978158,0.001284033,0.0001951364,0.000153708,0.00004710736,0.000375913,0.00001917456,0.000006572271,0.0001024939],"genre_scores_gemma":[0.9974882,0.00004611118,0.001451685,0.0000197323,0.0000552209,0.00003568411,0.0001230476,0.00001831199,0.000762005],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002864741,"threshold_uncertainty_score":0.4377622,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006215694300149657,"score_gpt":0.2381420497592392,"score_spread":0.2319263554590895,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}