{"id":"W2058827293","doi":"10.1021/pr9006987","title":"Identification of Novel Interacting Protein Partners of SMN Using Tandem Affinity Purification","year":2010,"lang":"en","type":"article","venue":"Journal of Proteome Research","topic":"Neurogenetic and Muscular Disorders Research","field":"Medicine","cited_by":39,"is_retracted":false,"has_abstract":true,"ca_institutions":"Ottawa Hospital; University of Ottawa","funders":"Canadian Institutes of Health Research","keywords":"Spinal muscular atrophy; Tandem affinity purification; Biology; Cell biology; Motor neuron; HEK 293 cells; Molecular biology; Computational biology; Affinity chromatography; Genetics; Biochemistry; Neuroscience; Gene; Spinal cord","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002152429,0.0003807817,0.0003327619,0.0002514559,0.0002600803,0.0004024114,0.0003305307,0.0003433845,0.0008346873],"category_scores_gemma":[0.0003074249,0.0001525714,0.0002952449,0.0003067863,0.0001552271,0.000242593,0.0003278295,0.0004950898,0.0007294918],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004708323,"about_ca_system_score_gemma":0.0002202046,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009089992,"about_ca_topic_score_gemma":0.002505499,"domain_scores_codex":[0.9997962,0.00003614983,0.00001313058,0.00003805616,0.00007968736,0.00003671858],"domain_scores_gemma":[0.999884,0.0000281839,0.00001690521,0.00001093033,0.00002716091,0.00003276428],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00005395865,0.00002039428,0.0004226866,0.00003101689,0.000009294024,0.0001323,0.00001649613,0.00005724405,0.9975482,0.0000601078,0.0000571195,0.00159114],"study_design_scores_gemma":[0.00002604758,0.0001622969,0.01053922,0.00001266952,0.00004660751,0.001628056,0.00005734342,0.004363818,0.976284,0.0001639184,0.006699031,0.00001705641],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9803962,0.002995953,0.01451873,0.0002345706,0.00002271233,0.0000680854,0.0003875608,0.0000843312,0.001291901],"genre_scores_gemma":[0.9590572,0.002238835,0.03155475,0.0001529099,0.00001969786,0.00006040166,0.003278572,0.00004794236,0.003589727],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0009089992,"threshold_uncertainty_score":0.003416121,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1842395649586399,"score_gpt":0.4847674788095392,"score_spread":0.3005279138508993,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}