{"id":"W2058827293","doi":"10.1021/pr9006987","title":"Identification of Novel Interacting Protein Partners of SMN Using Tandem Affinity Purification","year":2010,"lang":"en","type":"article","venue":"Journal of Proteome Research","topic":"Neurogenetic and Muscular Disorders Research","field":"Medicine","cited_by":39,"is_retracted":false,"has_abstract":true,"ca_institutions":"Ottawa Hospital; University of Ottawa","funders":"Canadian Institutes of Health Research","keywords":"Spinal muscular atrophy; Tandem affinity purification; Biology; Cell biology; Motor neuron; HEK 293 cells; Molecular biology; Computational biology; Affinity chromatography; Genetics; Biochemistry; Neuroscience; Gene; Spinal cord","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.005945474,0.00008377725,0.0003082587,0.000689654,0.00008611273,0.00002763335,0.0002666192,0.0001075817,0.00006886216],"category_scores_gemma":[0.004358116,0.00006888341,0.0001494854,0.0006791727,0.0002731797,0.0001613201,0.00007678098,0.001255213,0.000002749363],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00005925434,"about_ca_system_score_gemma":0.0008165972,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00003664458,"about_ca_topic_score_gemma":0.000005245045,"domain_scores_codex":[0.9969192,0.0002308141,0.0008856731,0.0001586056,0.001530932,0.0002747638],"domain_scores_gemma":[0.9960104,0.0001564098,0.0006711363,0.0003438898,0.002656443,0.0001617002],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002792003,0.0005750103,0.003251008,0.0003423454,0.00005728321,0.000007392568,0.0002315628,0.00001647341,0.9925214,0.0001291105,0.00001869471,0.002570519],"study_design_scores_gemma":[0.0013027,0.0004901752,0.01055645,0.0003403948,0.00002649076,0.0001280397,0.0005742713,0.001972438,0.9842041,0.0001421047,0.0002079397,0.00005490417],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9941659,0.0001020172,0.003689599,0.0005905114,0.00007059077,0.001176015,0.000002219002,0.000003248844,0.0001999036],"genre_scores_gemma":[0.9922386,0.00003502267,0.007400092,0.000002370072,0.000122112,0.00001983665,0.000001139205,0.00001886325,0.0001619564],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.008317305,"threshold_uncertainty_score":0.5453343,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1842395649586399,"score_gpt":0.4847674788095392,"score_spread":0.3005279138508993,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}