{"id":"W2058898205","doi":"10.1016/j.cellsig.2007.08.013","title":"MyD88, IRAK1 and TRAF6 knockdown in human chondrocytes inhibits interleukin-1-induced matrix metalloproteinase-13 gene expression and promoter activity by impairing MAP kinase activation","year":2007,"lang":"en","type":"article","venue":"Cellular Signalling","topic":"NF-κB Signaling Pathways","field":"Biochemistry, Genetics and Molecular Biology","cited_by":59,"is_retracted":false,"has_abstract":false,"ca_institutions":"Université de Montréal; Hôpital Notre-Dame","funders":"Canadian Arthritis Network; Canadian Institutes of Health Research","keywords":"Gene knockdown; MAPK/ERK pathway; RNA interference; Cell biology; p38 mitogen-activated protein kinases; Kinase; Transcription factor; Phosphorylation; Chemistry; Signal transducing adaptor protein; Signal transduction; Molecular biology; Proinflammatory cytokine; Protein kinase A; Biology; Gene; Biochemistry; Immunology; Inflammation; RNA","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0008316449,0.0003573814,0.0002988035,0.0001695994,0.000185342,0.00008743668,0.0001541579,0.0003348416,0.00001424607],"category_scores_gemma":[0.00004673675,0.0003649236,0.00007829304,0.0001207523,0.00006717185,0.00003868421,0.0001813837,0.0003202348,0.000001768636],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00006029787,"about_ca_system_score_gemma":0.00002918168,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00008147702,"about_ca_topic_score_gemma":0.00003469512,"domain_scores_codex":[0.99804,0.0001234301,0.0003917649,0.0007591788,0.0002157429,0.000469878],"domain_scores_gemma":[0.9992667,0.00003219993,0.0001966263,0.0002762703,0.00005868321,0.00016952],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001475542,0.0001162478,0.0006177,0.0001205147,0.00002644322,0.00003541941,0.000310637,0.00003738772,0.9970278,0.000003277421,0.00001384254,0.001543226],"study_design_scores_gemma":[0.001089089,0.0002745187,0.0002366974,0.0002250812,0.00002068643,0.00001352846,0.00007566196,0.0002752468,0.9971839,0.00005280425,0.0001413859,0.000411392],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9745557,0.001352465,0.02339492,0.00002466259,0.00005593466,0.0005413909,0.000006313736,0.00003789259,0.00003074548],"genre_scores_gemma":[0.997895,0.00002112519,0.001549897,0.00002661275,0.0001814371,0.00003038457,0.00009889794,0.00006309532,0.0001335507],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02333932,"threshold_uncertainty_score":0.9998803,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01224353118808332,"score_gpt":0.2459918490736449,"score_spread":0.2337483178855616,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}