{"id":"W2058898205","doi":"10.1016/j.cellsig.2007.08.013","title":"MyD88, IRAK1 and TRAF6 knockdown in human chondrocytes inhibits interleukin-1-induced matrix metalloproteinase-13 gene expression and promoter activity by impairing MAP kinase activation","year":2007,"lang":"en","type":"article","venue":"Cellular Signalling","topic":"NF-κB Signaling Pathways","field":"Biochemistry, Genetics and Molecular Biology","cited_by":59,"is_retracted":false,"has_abstract":false,"ca_institutions":"Université de Montréal; Hôpital Notre-Dame","funders":"Canadian Arthritis Network; Canadian Institutes of Health Research","keywords":"Gene knockdown; MAPK/ERK pathway; RNA interference; Cell biology; p38 mitogen-activated protein kinases; Kinase; Transcription factor; Phosphorylation; Chemistry; Signal transducing adaptor protein; Signal transduction; Molecular biology; Proinflammatory cytokine; Protein kinase A; Biology; Gene; Biochemistry; Immunology; Inflammation; RNA","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002949189,0.0004113258,0.0005666591,0.0002494491,0.0002792863,0.0003402429,0.0002913209,0.0003096375,0.002007653],"category_scores_gemma":[0.000166951,0.0002980647,0.0004750039,0.0001809955,0.0003801044,0.0002023522,0.0002262141,0.0007455205,0.0005854688],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002304777,"about_ca_system_score_gemma":0.0003768383,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008599677,"about_ca_topic_score_gemma":0.001591263,"domain_scores_codex":[0.9996896,0.00004551317,0.00005158612,0.00005362364,0.00005429777,0.0001053266],"domain_scores_gemma":[0.9998968,0.00001891355,0.0000264626,0.00001783616,0.00000819874,0.000031751],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0008848782,0.0001105409,0.0001376083,0.00009128619,0.00001528801,0.00006083813,0.00002271669,0.00005714129,0.9971991,0.00007713975,0.00009115753,0.001252249],"study_design_scores_gemma":[0.0001783365,0.001121111,0.004298473,0.000006473958,0.0000609201,0.0004472425,0.00006704241,0.0007446632,0.9908568,0.00004105492,0.002171576,0.000006213541],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9946967,0.002354944,0.001508142,0.000140363,0.00008709754,0.00003386586,0.0003193963,0.00008098417,0.0007784563],"genre_scores_gemma":[0.9937081,0.0008648173,0.001393883,0.00004837877,0.00002274866,0.00007027927,0.0004418976,0.00001377168,0.003436189],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002007653,"threshold_uncertainty_score":0.006716311,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01224353118808332,"score_gpt":0.2459918490736449,"score_spread":0.2337483178855616,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}